The expoCube is a novel Air Liquid Interface (ALI)/Transwell in vitro / ex vivo exposure system that efficiently deposits aerosols onto cells and tissues. Using Thermophoresis, which directs particles onto target tissues via a temperature gradient, the expoCube increases deposition rates from 2% to nearly 40%. Its integration with a Quartz Crystal Microbalance (QCM) enables real-time measurement of the deposited dose, providing precise control over experimental conditions.
When combined with SCIREQ’s inExpose® inhalation exposure platform, the expoCube allows researchers to integrate in vitro, ex vivo and in vivo models, optimizing compound usage while adhering to the 3Rs principle (replace, reduce, refine animal experiments).
| Specifications | Measurements |
|---|---|
| Dimensions (Width x Depth x Heigh) | 200x101x139 mm 7.87x3.98x5.47 in |
| Weight | 3 kg (6.61 lbs) |
| Internal volume (single channel): Primary flow volume: Micro flow volume: | 11.4 ml 0.65 ml |
| Temperature (exposure unit) | 30-55 C° |
| Differential pressure in the expoCube exposure unit | <+/- 1 mBar |
| Input OD tubing: Output OD tubing: | 12 mm 1/4 in |
| Wetted materials (not including tubing) | Teflon Stainless steel Silicon rubber (Elastosil RT 607) O-rings (Buna-N) Connectors (Nickel-Plated Brass) |
| Pore Size | Membrane Material | Corning Order Number |
|---|---|---|
| 0.4 μm | Polycarbonate | 3401 |
| 0.4 μm | Polyester | 3460 |
| 3.0 μm | Polycarbonate | 3402 |
| 3.0 μm | Polyester | 3462 |
| Pore Size | Membrane Material | Corning Order Number |
|---|---|---|
| 0.4 μm | PET | 353180 |
| 0.4 μm | High Density PET | 353494 |
| 1.0 μm | PET | 353103 |
| 3.0 μm | PET | 353181 |
| 3.0 μm | High Density PET | 353292 |
| PET | 8.0 μm | 353182 |
Save time evaluating SCIREQ equipment by having a SCIREQ Application Specialist conduct a custom
literature research. Researchers will receive an email report showing SCIREQ publications relevant to their specific application research area, along with custom equipment recommendations and commentary.
