The expoCube is a novel Air Liquid Interface (ALI)/Transwell in vitro exposure system that efficiently deposits aerosols onto cells and tissues. Using Thermophoresis, which directs particles onto target tissues via a temperature gradient, the expoCube increases deposition rates from 2% to nearly 40%. Its integration with a Quartz Crystal Microbalance (QCM) enables real-time measurement of the deposited dose, providing precise control over experimental conditions.
When combined with SCIREQ’s inExpose® inhalation exposure platform, the expoCube allows researchers to integrate in vitro and in vivo models, optimizing compound usage while adhering to the 3Rs principle (replace, reduce, refine animal experiments).
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