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SCIREQ & 3RsC hosted a virtual webinar on Maximizing Drug Development Efficiency Using Predictive in vitro and ex vivo Models on October 29th at 10-11 am EST via ZOOM.

The insightful webinar explored innovative strategies for enhancing drug development efficiency using predictive in vitro and ex vivo models. This session took a deep dive into the latest methodologies that bridge the gap between laboratory research and clinical applications, accelerating the drug development process.

Discover how the approach developed by the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) in Hannover, Germany, streamlines drug development by offering faster, cost-effective, and predictive methods for developing new inhalable therapeutics.

Key highlights included:

  • Precision Cut Lung Slices (PCLS): Used to study drug efficacy and respiratory toxicity of inhalable drugs
  • Application of PRIT expoCube system: Enabling dose controlled air-liquid-interface exposure
  • Therapeutic window: Identification of a therapeutic window between efficacy and local toxicity
  • Integration of in vitro and in vivo Data: Using computational models to establish toxicity thresholds and first dose estimates

Download the event summary:

Speaker Spotlight

Dr. Katharina Schwarz

Dr. Katharina Schwarz (f) leads the department “Inhalation and Aerosol Sciences” at the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) in Hannover, Germany.

She is an expert at the interface between aerosol/inhalation research, respiratory pharmacokinetics, toxicology/physiology, and inhalation exposure science with a special focus on particle lung dosimetry and biophysical particle-lung interactions. In her institutional role she is responsible for the aerosol aerosol/inhalation and dosimetry-related/QIVIVE-related aspects in drug development programs as well as toxicological and inhalation exposure studies including GLP/GCP-compliance. Customers are major pharmaceutical, chemical and cosmetic companies from Europe and US as well regulatory authorities.

In Vivo and In Vitro Exposure

The expoCube provides a novel ALI (air liquid interface) culture exposure system, integrating with the inExpose system’s existing exposure generators such as the integrated cigarette smoking robot and industry leading e-cigarette extensions.

The expoCube features:

  • Reproducibility: Efficient, uniform, and precise exposure of particulates onto target cells and tissues.
  • Precision: Optimized flow paths using advanced computational fluid dynamics (CFD) modelling.
  • Deposition: Patented thermophoresis, increasing the deposition efficiency of small particles without imparting unnatural electrostatic charges onto the aerosols.

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