Precision-Cut Lung Slices (PCLS) help researchers understand pathophysiological mechanisms associated with various respiratory diseases. The physioLens is a scientific platform that provides accurate physiological and image-based outcomes in a reproducible fashion. It includes an automated microscope and fluid handling system
The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM and SCIREQ Scientific Respiratory Equipment Inc. are pleased to announce their collaboration for the development and commercialization of the expoCube platform. The expoCube is a precision aerosol exposure system for pulmonary research. It permits highly accurate and reproducible deposition of particles from inhalable aerosols onto cells and tissues from the lungs.
The flexiVent is widely regarded as the gold standard for in vivo lung function measurements. It goes beyond traditional resistance and compliance measurements, and captures crucial details about the mechanical properties of conducting airways, terminal airways and parenchyma.
The flexiVent achieves the highest sensitivity and reproducibility by precisely controlling experimental conditions.
The inExpose is designed to operate under a standard fume hood, and distinguishes itself by its compact size and high level of integration. Its modularity and integration permits both nose-only and/or whole body exposure of rodents, as well as automated generation of cigarette smoke and aerosols. The small form factor reduces direct and indirect costs, and low internal volumes also minimize unintended dilution of precious compounds.
Plethysmography is a standard method for studying pulmonary function in conscious, spontaneously breathing laboratory subjects. The barometric plethysmography technique measures flow and pressure changes that occur while the subject is breathing, before and after exposure to a drug or other challenges. It is easily adapted to various subject sizes and species, and is often used for longitudinal studies where the subjects are studied for multiple hours on successive experiment days.
In the quest for better treatment options, precision cut lung slices (PCLS) have emerged as a cutting-edge tool in preclinical asthma research
As researchers strive to bridge the gap between preclinical investigations and clinical outcomes, the accurate assessment of Forced Expired Volume (FEV) and Forced Vital Capacity (FVC) emerges as a cornerstone for establishing translational relevance.
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
Opioid-related addiction, overdose and death is a widespread public health crisis. A recent paper provides a model example of the how plethysmography can be used to assess ventilatory behavior changes that occur with opioid administration.
Arsenic trioxide (ATO) is an inorganic arsenical that poses significant environmental and public health risks due to its toxic nature. While it is widely used in various industrial and medicinal applications, the potential harm caused by intentional or accidental exposure cannot be overlooked.
Dr. Vanoirbeek is a research Associate Professor at KU Leuven. His interests are occupational and environmental exposure assessment and toxicology, with a special focus on experimental lung immune toxicology. Learn more about his work in this interview!
Dr. Davis is a PI in the Department of Veterinary Biosciences at The Ohio State University. Research in the Davis lab is focused on the pathophysiologic effects of pulmonary viral infections. Learn more about his work in this interview!
Dr. Carolyn Baglole is an Associate Professor in the Department of Medicine at McGill University. Her laboratory focuses on how chronic lung diseases such as COPD are associated with environmental exposures, particularly cigarette smoke.
Learn what Dr. Harry
Karmouty-Quintana, a scientist at the forefront of the preclinical idiopathic pulmonary fibrosis (IPF) research field, has to say about his research and the current state and future of the field.
The Wold lab studies the effects of E-cigarettes use on the cardiovascular system in a preclinical model. We sat down with him to learn more about his research and get his thoughts on the state of inhalation toxicology research.
The Halayko lab focuses on the pathogenesis of bronchial asthma and is at the forefront of preclinical asthma research. We sat down with Dr. Halayko to learn more about his thoughts on the current state and future of asthma research.
Welcome to SCIREQ’s knowledge center. You can find everything from software registration to document downloads to complete list of SCIREQ publications in this section. Everything you need to get the most out of your SCIREQ system.