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State of Cannabis Research

State of cannabis research Since the recent legalization of recreational cannabis, there is an increased interest in research into both the pulmonary effects of inhaled cannabis, as well as improving our understanding of the endocannabinoid

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Advantages of ALI Exposure – expoCube

Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.

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Tissue Baths in Respiratory Disease Models

Isolated tissue baths, also known as organ chambers, are tools that have been used in the discipline of pharmacology for over 150 years to evaluate tissues contractility and relaxation response upon exposure to stimuli including the addition of various agonists1. This technique was used in one of the most breakthrough scientific findings in 1980 when the endothelium pioneers, Furchgott and Zawadski, discovered the signalling molecule nitric oxide in the cardiovascular system2 for which they were awarded the 1998 Nobel Price in physiology.

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Pulmonary Vascular Remodeling

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lungs that has been a major public health problem, and has been the third leading cause of death worldwide. A large proportion of COPD deaths (~75%) are linked to tobacco smoking, which is now the primary risk factor in the development of the disease.

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Reversal of Emphysema by Restoration of Pulmonary Endothelial Cells

Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease that is associated with exposure to inhaled irritants such as cigarette smoke and environmental pollutants. COPD is marked by airway inflammation and emphysema, leading to airflow obstruction and respiratory failure. The pathway to the development of COPD is yet to be fully understood but long-term inflammation is thought to be one of the main drivers.

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Latest Advances in Preclinical SARS-CoV-2 Research

There has been incredible scientific effort and progress over the past two years geared at the protection and treatment of COVID-19. In this blog, we will highlight some significant recent advances in SARS-CoV-2 preclinical modelling, which use the inExpose to deliver inhaled target compounds and the flexiVent to characterize a full pulmonary function profile.

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Dual Vaccination Protects Against Allergic Asthma in Mice

Dual vaccination against IL-4 and IL-13 using kinoids (a conjugate vaccine) is one of the therapeutic strategies suggested to neutralize the response induced by this type 2 inflammation. In recent studies by Conde et al 2021, House Dust Mite (HDM)-treated mice, which exhibit key characteristics of human chronic asthma, were used to test prophylactic and therapeutic dual vaccination efficiency in this allergic mouse model.

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New Mouse Handling Recommendations For Improving Animal and Handler Well-being

All research model systems have unique strengths and challenges regarding the generalizability of data to other systems. Pre-clinical researchers attempt to describe and interact with human clinical phenotypes using animal models. These models allow manipulation and testing of scientific hypotheses within the context of a complex system, providing insights that may be impossible using in vivo methods or within the constraints of clinical interventions.

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Ending Support for Legacy Plethysmography

Our legacy plethysmograph system has officially retired starting September 1, 2019.

Over the past few years it has become increasingly difficult to support our legacy plethysmography data acquisition hardware and software, with considerable rises in costs associated with maintenance and support for existing systems. After careful consideration, it was decided to retire the legacy plethysmograph system.

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Mucolytic Treatment in Allergic Airway Disease

Asthma is a complex disease, whose principal characteristics include reversible airflow obstruction, airway hyperresponsiveness (AHR), airway inflammation, airway remodeling and mucus hypersecretion. Airway mucus hypersecretion specifically is an important and dangerous pathophysiological manifestation of asthma.

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American Thoracic Society 2022

This years ATS meeting took place in San Francisco, and our team was there to show off the new and exciting developments that you have come to expect from SCIREQ. With recent developments to both the flexiVent and inExpose systems, there was a lot to see. Come stay updated.

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Assessing the Airway Contribution To Total Respiratory Compliance

The airways contribute to the total compliance of the respiratory system and, over the last 50 years or so, researchers have had an interest in establishing their specific contribution Indeed, the airway diameter as well as the volume of air available for ventilation following inspiration can both be affected by a change in the distensibility of the airways.

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Empowering researchers

Welcome to SCIREQ’s knowledge center. You can find everything from software registration to document downloads to complete list of SCIREQ publications in this section. Everything you need to get the most out of your SCIREQ system.