Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Since COVID-19 was declared a global pandemic in March 2020, a massive wave of mobilization has been seen from various companies and organizations at different fronts
State of cannabis research Since the recent legalization of recreational cannabis, there is an increased interest in research into both the pulmonary effects of inhaled cannabis, as well as improving our understanding of the endocannabinoid
Volatile organic compounds (VOCs) in breath are emerging as vital biomarkers in medical research, offering a non-invasive glimpse into metabolic and physiological processes. A recent publication by Talor, A., et al (2024) has introduced a novel method for capturing VOCs from the breath of intubated mouse models.
Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in the MECP2 gene, leading to various symptoms, including cognitive impairment, motor dysfunction, and significant respiratory abnormalities.
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses.
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs, which severely impairs lung function over time.
Lung function testing (LFT) is crucial for diagnosing and monitoring chronic lung diseases like idiopathic pulmonary fibrosis (IPF). In animal studies, particularly with mice, LFT is often used as an endpoint, requiring multiple animals to assess disease progression.
A recent publication by Boucher et al (2024) streamlines this process of quantifying airway constriction in Precision Cut Lung Slices (PCLS) by using the new physioLens automated solution for physiology and image analysis. This new solution enables researchers to conduct high-throughput screening of airway constriction with unprecedented precision and efficiency.
Idiopathic pulmonary fibrosis (IPF) remains a devastating condition with limited treatment options, often leading to a grim prognosis. However, a recent study by Milman-Krentsis (2024) offers a beacon of hope, demonstrating the potential of lung cell transplantation as a therapeutic intervention for lung fibrosis.
The incidence of landscape fires has been rising globally, leading to increased exposure to landscape fire smoke (LFS) among millions of people. The inhalation of particulate matter (PM) from LFS is associated with adverse respiratory and cardiovascular outcomes.
Recent advances in the fight against severe acute inflammatory lung diseases, including COVID-19, have revealed a promising new approach to treating pulmonary hyperinflammation and long-term lung damage such as fibrosis.
Recent advances in the fight against severe acute inflammatory lung diseases, including COVID-19, have revealed a promising new approach to treating pulmonary hyperinflammation and long-term lung damage such as fibrosis.
Tuberculosis and Human Immunodeficiency Virus are major global health threats. Their interaction worsens disease severity, as HIV reduces CD4+ T cells, making individuals more vulnerable to TB.
A recent study by Yang, F., et al (2024) has explored the potential of bacteriophage therapy for treating multi-drug resistant Mycobacterium tuberculosis (Mtb) infections
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