Resources

Build on your knowledge of various topics in pre-clinical pulmonary research including animal models used in pulmonary research studies, study design, grant justifications and more.

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Animal Models

Small animal models of pulmonary fibrosis

Learn more about the most common small animal fibrosis models, along with a brief description of their modes of induction, advantages, and disadvantages.

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Animal Models

Asthma Animal Models

This resource delves into the most popular asthma animal models, the advantages and disadvantages of each, what goes into a successful model, the sensitization and challenge phases, and more!

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Animal Models

COPD ANIMAL MODELS

Learn what goes into a successful COPD model, the types of models available, what the pros and cons of each model are, which species or strains are better and why.

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Study Design

The flexiVent and Fibrosis Research

Learn more about the physiology of fibrosis, understanding flexiVent measurements and outcomes for fibrosis research, and gated thoracic imaging with the flexiVent

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Study Design

Grant Justifications for Equipment

These documents will include an overview of the equipment, unique features, and specific diseases the equipment can be used for to help you write your grant justification.

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Animal Models

Animal models of COVID-19

Learn more about the current research, as leading preclinical researchers delve into the advantages and disadvantages of various COVID-19 animal models.

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Study Design

Moving Into In Vivo Research

While working with in vivo models can be challenging, SCIREQ makes in vivo lung function measurements accessible to scientists of all backgrounds. Learn more about getting started with in vivo studies in this document.

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Study Design

ARDS research with the flexiVent

In this short video, learn about the physiology of ARDS, understanding flexiVent measurements and outcomes for ARDS research, and a typical protocol for ARDS studies

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Study Design

New Mouse Handling Recommendations

Animal models bridge the gap between in vitro studies and studies in humans. Many institutions have recently adopted new guidelines for mouse handling that appears to improve both animal and caretaker welfare. Get the details on the latest protocol here.

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Study Design

ANESTHESIA REGIMES FOR FLEXIVENT STUDIES

Learn about the anesthesia regimes for flexiVent studies. This includes recommended anesthetic and paralytic regimes, types of anesthetics used and more.

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Study Design

STUDYING COVID19 WITH THE FLEXIVENT

The flexiVent measures detailed lung function outcomes in infected animals, genetic knock-outs and treatment groups, allowing scientists to test their hypotheses in complex organisms that closely recapitulate human biology.

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Fundamentals

Fundamentals of Respiratory Physiology

Understanding the basic aspects of respiratory physiology and lung function measurements are of prime importance to best appreciate the potential of these outcomes and interpret experimental results.

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Study Design

Asthma Research and the flexiVent

The flexiVent goes beyond traditional resistance and compliance measurements, and captures crucial details about the mechanical properties of the lung making it an invaluable tool to further elucidate asthma pathophysiology

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Study Design

flexiVent Methods & Protocol

This protocol describes the procedures required to perform forced-oscillation measurements of respiratory mechanics in mice using the flexiVent

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Study Design

Advancing COPD research

In this short video, learn about the physiology of COPD, measuring lung function with the flexiVent, and the outcomes from the flexiVent for COPD studies

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Study Design

LAB HANDBOOK

Created in collaboration with Samuel Mehr from The Music Lab at Harvard, this is the ultimate guide for what to include when creating or enhancing your lab handbook.

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Study Design

Bronchoalveolar Lavage Protocol

Learn the steps and procedures required to adequately perform a bronchoalveolar lavage (BAL) following measurements of respiratory mechanics in mice using the flexiVent systems in this BAL protocol.

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Animal Models

IACUC Considerations

Any activities that involve animals in research must first be approved by the International Animal Care and Use Committee who play a key role in ensuring the humane use and care of these animals.. Learn what details are important for IACUC.

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Study Design

RECOMMENDED PARAMETERS PER DISEASE

This document provides a summary of diseases and research applications with the key flexiVent manoeuvres and associated parameters that should be considered.

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Study Design

E-CIGARETTE PROFILES USED WITH THE INEXPOSE

This document will help guide your decisions by providing a clear understanding of the components affecting puff topography along with a literature review of the three most common profiles used in e-cigarette research.