Build on your knowledge of various topics in pre-clinical pulmonary research including animal models used in pulmonary research studies, study design, grant justifications and more.
Small animal models of pulmonary fibrosis
Learn more about the most common small animal fibrosis models, along with a brief description of their modes of induction, advantages, and disadvantages.
Asthma Animal Models
This resource delves into the most popular asthma animal models, the advantages and disadvantages of each, what goes into a successful model, the sensitization and challenge phases, and more!
COPD ANIMAL MODELS
Learn what goes into a successful COPD model, the types of models available, what the pros and cons of each model are, which species or strains are better and why.
The flexiVent and Fibrosis Research
Learn more about the physiology of fibrosis, understanding flexiVent measurements and outcomes for fibrosis research, and gated thoracic imaging with the flexiVent
Grant Justifications for Equipment
These documents will include an overview of the equipment, unique features, and specific diseases the equipment can be used for to help you write your grant justification.
Animal models of COVID-19
Learn more about the current research, as leading preclinical researchers delve into the advantages and disadvantages of various COVID-19 animal models.
Moving Into In Vivo Research
While working with in vivo models can be challenging, SCIREQ makes in vivo lung function measurements accessible to scientists of all backgrounds. Learn more about getting started with in vivo studies in this document.
ARDS research with the flexiVent
In this short video, learn about the physiology of ARDS, understanding flexiVent measurements and outcomes for ARDS research, and a typical protocol for ARDS studies
New Mouse Handling Recommendations
Animal models bridge the gap between in vitro studies and studies in humans. Many institutions have recently adopted new guidelines for mouse handling that appears to improve both animal and caretaker welfare. Get the details on the latest protocol here.
ANESTHESIA REGIMES FOR FLEXIVENT STUDIES
Learn about the anesthesia regimes for flexiVent studies. This includes recommended anesthetic and paralytic regimes, types of anesthetics used and more.
STUDYING COVID19 WITH THE FLEXIVENT
The flexiVent measures detailed lung function outcomes in infected animals, genetic knock-outs and treatment groups, allowing scientists to test their hypotheses in complex organisms that closely recapitulate human biology.
Fundamentals of Respiratory Physiology
Understanding the basic aspects of respiratory physiology and lung function measurements are of prime importance to best appreciate the potential of these outcomes and interpret experimental results.
Asthma Research and the flexiVent
The flexiVent goes beyond traditional resistance and compliance measurements, and captures crucial details about the mechanical properties of the lung making it an invaluable tool to further elucidate asthma pathophysiology
flexiVent Methods & Protocol
This protocol describes the procedures required to perform forced-oscillation measurements of respiratory mechanics in mice using the flexiVent
Advancing COPD research
In this short video, learn about the physiology of COPD, measuring lung function with the flexiVent, and the outcomes from the flexiVent for COPD studies
Created in collaboration with Samuel Mehr from The Music Lab at Harvard, this is the ultimate guide for what to include when creating or enhancing your lab handbook.
Bronchoalveolar Lavage Protocol
Learn the steps and procedures required to adequately perform a bronchoalveolar lavage (BAL) following measurements of respiratory mechanics in mice using the flexiVent systems in this BAL protocol.
Any activities that involve animals in research must first be approved by the International Animal Care and Use Committee who play a key role in ensuring the humane use and care of these animals.. Learn what details are important for IACUC.
RECOMMENDED PARAMETERS PER DISEASE
This document provides a summary of diseases and research applications with the key flexiVent manoeuvres and associated parameters that should be considered.
E-CIGARETTE PROFILES USED WITH THE INEXPOSE
This document will help guide your decisions by providing a clear understanding of the components affecting puff topography along with a literature review of the three most common profiles used in e-cigarette research.