Resources
Build on your knowledge of various topics in pre-clinical pulmonary research including animal models used in pulmonary research studies, study design, grant justifications and more.
PCLS Resource Hub
The ultimate resource page for your preclinical Precision Cut Lung Slice research needs!
Preclinical Fibrosis Resource Hub
The ultimate resource page for your preclinical fibrosis research needs!
Respiratory Function in Preclinical Models of Alpha-1 Antitrypsin Deficiency
Read more about a recently published study out of Drs. Engelhardt and Rosen’s laboratory which investigates a longitudinal approach to looking at pulmonary impairment in
Complementing Plethysmography Pulmonary Function with Detailed Respiratory Mechanics Measurements
This document highlights the advantages of Plethysmography and Detailed Respiratory Mechanics Measurements in providing the most complete respiratory phenotype for your model.
Plethysmography Techniques & Respiratory Science
Erica Levitt, PhD, from the University of Florida, and Lara DeRuisseau, PhD, from Le Moyne College in Syracuse, New York, present their research on the
Ventilator Assisted Aerosol Delivery (VAAD)
This document covers VAAD homogenous deposition patterns, VAAD for disease modeling and VAAD for drug delivery.
E-cigarettes induce cardiac arrhythmia and conduction defects in mice
This document provides a summary of this study by Dr. Carll et al. at the University of Louisville published in Nature Communications.
Considerations for Pre-Clinical Smoke Exposure Studies
In our recent panel discussion event, we explored the considerations for performing inhalation exposure studies with cigarettes, e-cigarettes, and cannabis.
E-cigarette Profiles Used With the inExpose
This document will help guide your decisions by providing a clear understanding of the components affecting puff topography along with a literature review of the
Recommended Parameters Per Disease
This document provides a summary of diseases and research applications with the key flexiVent manoeuvres and associated parameters that should be considered.
IACUC Considerations
Animal models are crucial to preclinical respiratory research as they help in improving the understanding of disease pathways and assessing potential therapies. Any activities that
Bronchoalveolar Lavage Protocol
Learn the steps and procedures required to adequately perform a bronchoalveolar lavage (BAL) following measurements of respiratory mechanics in mice using the flexiVent systems in
23 Things You Should Include in Your Lab Handbook
Created in collaboration with Samuel Mehr from The Music Lab at Harvard, this is the ultimate guide for what to include when creating or enhancing
How can the flexiVent advance your COPD research?
In this short video, learn about the physiology of COPD, measuring lung function with the flexiVent and the outcomes from the flexiVent for COPD studies.
flexiVent Methods & Protocol
Access our standard operating procedure to obtain forced oscillation measurements of respiratory mechanics in anesthetized mice and to assess airway responsiveness to methacholine.
Advancing Asthma Research With the flexiVent
In this short video, learn more about the physiology of asthma. You will also understand flexiVent measurements and outcomes for asthma research,with a drug discovery
Understanding Respiratory Physiology
Understanding the basic aspects of respiratory physiology and lung function measurements are of prime importance to best appreciate the potential of these outcomes and interpret
The flexiVent & COVID-19 Studies
In this short video, learn about pathophysiology of SARS-CoV-2 infection, preclinical models of COVID-19 and measurement capabilities of the flexiVent for COVID studies.
Anesthesia Regimes for flexiVent Studies
flexiVent experiments provide lung function outcomes with a high degree of sensitivity and reproducibility using even small subject groups. This process requires invasive interventions of