The physioLens™ is a Precision-Cut Lung Slice (PCLS) imaging research platform designed as a turnkey solution for automated airway contractility, dose response, cilia beating and calcium imaging studies in pulmonary tissues derived from mice, rats, pig or human lungs. The system uniquely combines high-speed imaging, 3-channel fluorescent microscopy and precision 3-axis positioning to yield high quality images with predictive physiological outcomes in a highly automated instrument.
Asthma involves excessive airway smooth muscle contraction and heightened sensitivity, causing bronchoconstriction and hyperresponsiveness. The analysis of PCLS with the physioLens allows precise characterization of individual airways, offering data on their size, shape, and location while eliminating external influences. This approach also enables detailed assessment of airway smooth muscle contractility, a critical factor in asthma pathophysiology.
The physioLens enhances pulmonary hypertension research with high-throughput analysis of lung tissue from animals to humans. Its combination of brightfield and fluorescence microscopy, automated detection, and real-time contractility measurements enables precise studies of calcium dynamics and vascular responses. The perfusion setup ensures stable dosing and imaging. The added ability to measure cilia beating frequency provides new insights into airway and vascular health, advancing understanding of disease mechanisms and treatments.
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literature research. Researchers will receive an email report showing SCIREQ publications relevant to their specific application research area, along with custom equipment recommendations and commentary.
