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Pulmonary Hypertension

Pulmonary hypertension (PH) is a condition characterized by elevated blood pressure in the arteries of the lungs, often leading to heart failure if left untreated. Preclinical research on PH involves various approaches to understand its pathophysiology and develop potential treatments. Animal models, particularly rodents and larger mammals, are commonly used to mimic PH conditions and study disease mechanisms. Researchers employ techniques such as hemodynamic measurements, right ventricular and pulmonary function, histology, and molecular analyses to assess pulmonary vascular remodeling, inflammation, and cardiac function in these models. Additionally, in vitro studies using cell cultures and ex vivo tissue preparations provide valuable insights into cellular and molecular pathways underlying PH progression. By combining these preclinical methods, scientists aim to uncover novel therapeutic targets and interventions to mitigate the devastating effects of pulmonary hypertension.

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Comprehensive and integrated assessment

In preclinical cardiopulmonary research, the challenge is often to link structural or physical changes (e.g. narrowing of pathways or build of up edema) to altered lung function measurements, such as resistance, compliance or spirometry outcomes. The flexiVent is a comprehensive tool allowing an integrated assessment of various disease determinants (e.g. extent and pattern of induced damage) on lung function decline. It measures the mechanical properties of the lungs with high sensitivity and reproducibility, providing clinically relevant outcomes.

References & Publications


Contractility measures simplified

emkaBATH is a type of tissue bath setup, designed for contractile measures in tissues such as aortic, tracheal, iliac, and papillary muscles, and/or microvessels such as veins, small arteries, and lymph vessels. The system provides heated, oxygenated, and nutrient-rich perfusate to the tissue with or without drug administration and electrical stimulation.

Tissue baths are widely used to study the effects of agonists and antagonists on tissue contractility. Dose-response curves allow for characterization of a drug’s pharmacological profile and the calculation of EC50 or Emax.

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Symptom screening

Whole-body plethysmography can be an easy tool for screening subjects quickly for preliminary respiratory data with the option of delivering inhaled therapeutics. Ventilatory parameters (e.g. breathing frequency, tidal volume, peak inspiratory or expiratory flows) can be measured noninvasively in conscious animals providing indicators of pulmonary changes in various cardiopulmonary models. IOX Software can seamlessly integrate pulmonary and cardio data for joint data collection and analysis.

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Perfusion system

The isolated heart perfusion system is a versatile solution to investigate small mammalian heart function, in health and disease, or following drug challenges.

Using either the Langendorff or the Working Heart technique, it allows the simultaneous assessment of cardiac electrophysiological and mechanical parameters (ECG, LVP, perfusion flow & pressure, etc.).

The isolated heart perfusion system provides highly reproducible experimental conditions to ensure survival of the isolated heart during several hours.

References & Publications


Reliable physiological biopotential signals

easyTEL implantable telemetry acquires multiple biopotentials (EEG, EMG, ECG, EOG), blood pressure, temperature, and activity.

While the small animal implants acquire up to 2 biopotentials for up to 150 days, the large animal implants can record up to 4 biopotentials for up to 125 days.

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