E-Cigarette & Vaping

The harmful effects of tobacco smoke exposure are well documented. Yet research is still necessary to understand the underlying pathophysiological mechanisms and there is a pressing need for new therapeutic agents to treat patients. Scientific evidence is also needed to understand the risks associated with vapour exposure from electronic cigarettes (e-cigarettes) in order to guide the decision-making process for the use of these nicotine delivery devices. The rapid adoption of e-cigarettes, especially amongst the youth, has spurred a rush to fill the knowledge gap pertaining to the safety profile for the users and the environment. Learn more from an expert at the forefront of e-cigarette research.

For more information on our pulmonary equipment for classic cigarette and cannabis exposure studies, please feel free to visit our Tobacco and Cannabis Studies page.

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countermeasures effects on respiratory system

VERSATILE, PROGRAMMABLE, REPRODUCIBLE

As a broad overview, an Electronic Nicotine Delivery Systems (ENDS) unit is a battery-powered device which heats up a metal resistive coil to produce an inhalable vapour of an e-liquid, without tobacco combustion. This e-liquid typically consists of Propylene Glycol (PG) and Vegetable Glycerin (VG) along with optional nicotine or flavourings. Originally designed to provide a perceived safer alternative and cessation tool for cigarette addition, the clinical risks associated with ENDS use, effectiveness for smoking cessation and overall toxicity are highly controversial.

Since studies assessing the impact of smoke are typically conducted over a prolonged time period, it is therefore important to consistently and reproducibly introduce the same smoke composition for each experimental session. To best create these translatable pre-clinical animal models, it is necessary to standardize factors such as puff frequencies and topographies, exposure concentrations, e-liquid composition and device generation/brand to ensure consistent E-cigarette Vapour Deposition. Using the inExpose system, researchers create accurate and reproducible models of smoke exposure using automated generation of vapour along with customizable puffing volumes and frequencies.

There are two different e-cigarette accessories for the inExpose system, MOD-e-cigarettes and Pod style e-cigarettes, both capable of customizable puffing profiles.

References

The recent publication by Noël et al. entitled Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies, is a noteworthy example to accelerate and harmonize e-cig research findings through the use of reproducible exposure environments.

countermeasures effects on respiratory system

QUANTITATIVE, INTEGRATIVE AND TRANSLATIONAL OUTCOMES

The structural and inflammatory impact of e-cigarette smoke exposure on the respiratory system can be characterized by evaluating detailed changes in lung function. The flexiVent permits a detailed lung function assessment, including lung compliance, mechanical properties of the parenchyma, pressure volume loops, total lung volumes along with clinically-translatable forced expired volumes & capacities (FEV/FVC).

References


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