E-Cigarette & Vaping

As a broad overview, an Electronic Nicotine Delivery Systems (ENDS) unit is a battery-powered device which heats up a metal resistive coil to produce an inhalable vapour of an e-liquid, without tobacco combustion. This e-liquid typically consists of Propylene Glycol (PG) and Vegetable Glycerin (VG) along with optional nicotine or flavourings. Originally designed to provide a perceived safer alternative and cessation tool for cigarette addition, the clinical risks associated with ENDS use, effectiveness for smoking cessation and overall toxicity are highly controversial.

Since studies assessing the impact of smoke are typically conducted over a prolonged time period, it is therefore important to consistently and reproducibly introduce the same smoke composition for each experimental session. To best create these translatable pre-clinical animal models, it is necessary to standardize factors such as puff frequencies and topographies, exposure concentrations, e-liquid composition and device generation/brand to ensure consistent E-cigarette Vapour Deposition. Using the inExpose system, researchers create accurate and reproducible models of smoke exposure using automated generation of vapour along with customizable puffing volumes and frequencies.

There are two different e-cigarette accessories for the inExpose system, MOD-e-cigarettes and Pod style e-cigarettes, both capable of customizable puffing profiles.