The expoCube is engineered to create an efficient, uniform, and precise exposure of particulates onto target cells and tissues. Its flow paths were designed and optimized using advanced computational fluid dynamics (CFD) modelling. Therefore, they allow a uniform deposition of airborne particles on the target cells, regardless of the particle size. The expoCube’s patented use of thermophoresis increases the deposition efficiency of small particles without imparting unnatural electrostatic charges onto the aerosols.
Aerosol exposure studies conducted at the air/liquid interface are more scientifically relevant and predictive of human biology than in vitro studies conducted in submerged culture. In addition, the use of Transwells® permeable supports allows cells to uptake and secrete molecules separately on both their basal and apical surfaces, thereby carrying out metabolic activities in a more natural fashion. The expoCube replicates human physiology more closely than traditional cellular exposure systems by preventing the exposure of the culture medium (i.e. the blood side) to the gas phase, thereby creating a more natural or “lung-like” exposure profile.
The expoCube exposes cells seeded on standard Transwell well plate inserts from Costar or Falcon. The use of standard commercial airway/liquid interface plates allow scientists to carry out different steps of the experimental process (e.g. cell culture, aerosol exposure, biological assays) on a single plate, from start to finish. This all-in-one plate ensures a productive workflow and minimizes the chances of handling errors. The expoCube design is therefore ideally suited for repeat-dose in vitro studies.
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