Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.
Oxygen saturation is the fraction of oxygen-saturated hemoglobin relative to total hemoglobin (unsaturated + saturated) in the blood. A very precise and specific balance of oxygen in the blood is necessary to keep the body functioning properly. Monitoring these changes provides complimentary outcomes and a means to quantify subject stress during an experiment.
QuickPrime Measurements for Deeper Insight What is the forced oscillation technique (FOT)? Simply put, the forced oscillation technique is: Pausing ventilation Sending a test signal
Since COVID-19 was declared a global pandemic in March 2020, a massive wave of mobilization has been seen from various companies and organizations at different fronts
New Insights From Pressure-volume Loops Lung function measurements with the flexiVent frequently include Pressure-Volume (PV) loops for insight on the intrinsic elastic properties of the respiratory system.
Electronic Nicotine Delivery Systems (ENDS) Electronic nicotine delivery systems (ENDS) are gaining in popularity in recent years. As a broad overview, an ENDS unit is
What You Always Wanted To Know About Specific Airway Resistance Specific airway resistance (sRaw), or its reciprocal specific airway conductance (sGaw), was first introduced over
Recent study succeeded to develop the first idiopathic pulmonary fibrosis mouse model. Lung function measurements were performed with the flexiVent.
At each breath, the respiratory system must overcome two opposing forces to be able to move air in and out of the lungs: the resistance to airflow and the distensibility (or compliance) of the respiratory system. Physiological and/or pathological factors may alter these mechanical characteristics and induce significant changes in the effort required to breathe or tolerance to exercise.
Idiopathic pulmonary fibrosis remains one of the most challenging respiratory diseases to treat, however new strategies that directly interrupt the cellular drivers of fibrosis are urgently needed.
Idiopathic pulmonary fibrosis remains one of the most challenging respiratory diseases to treat, however new strategies that directly interrupt the cellular drivers of fibrosis are urgently needed.
Asthma has reached epidemic proportions worldwide and typically starts early in life. It is a complex disease that can be both chronic and heterogeneous, its causes are multifactorial, including genetic, viral, obesity, and a wide arrange of environmental factors.
Since the recent legalization of recreational cannabis, there is an increased interest in research into both the pulmonary effects of inhaled cannabis, as well as improving our understanding of the endocannabinoid system.
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