Acute lung injury (ALI) arises from factors as diverse as endotoxin exposure, chemical assault, acute particulate exposures or mechanical impacts, as seen in ventilator induced lung injury (VILI). ALI...
Longitudinal studies offer a wealth of information, particularly for diseases progression or development studies. In addition, smaller sample sizes are possible to accumulate significant data, as subject assessment is...
Animal models are crucial in advancing our knowledge and understanding of pulmonary diseases. Using alternatives models, such as computer simulations, is simply not advanced enough to elucidate all the...
Work of Breathing & Airway Compliance The latest release of flexiWare (8.2) brings with it the capacity to assess both work of breathing (WOB) and airway compliance, expanding the...
Ultrapotent Miniproteins Protect Against SARS-CoV-2 Lung Inflammation and Pathology A recent study published in Cell Host & Microbe by Dr. Michael Diamond’s group at the University of Washington investigated...
Preclinical Neonate Research Preclinical Pediatrics and Neonate Research Pediatrics and neonatology involves learning more about development and growth through the first stages of life. Early lung development studies investigate the...
Asthma – From Mouse To Man “The assessment of lung function endpoints used in preclinical drug testing may hold the key to translation of drug efficacy from mouse to...
Atelectasis or airway closure spontaneously develops following anaesthesia and mechanical ventilation. This progressive loss in lung volume can have a significant impact on the subject’s
The current state-of-the-art in pre-clinical lung function measurements is the evaluation of the mechanical properties of the respiratory system using FOT.
Mice strain can have an important impact on research, as certain strains are better suited to some applications than others.
Viruses are constantly changing through mutation, and currently, there are several variants of the SARS-CoV-2 virus that causes COVID-19.
Throughout the global COVID-19 pandemic, there has been a noticeably higher mortality rate in males compared to females. Though the mechanism that causes this remains unknown, Dr. Sharma and...
Viruses are constantly changing through mutation, and currently, there are several variants of the SARS-CoV-2 virus that causes COVID-19.
In May 2021, SCIREQ had the pleasure of hosting a virtual panel discussion with leading preclinical infectious disease researchers focusing on Preclinical Models of COVID-19.
he ERS Lung Science Conference (LSC) is at the forefront of basic and translational respiratory science. SCIREQ looks forward to attending this event each year
Kumar et al. (2020) recently published a novel manuscript that combined work on cellular and mouse models shows that hyperglycemic conditions and the resultant metabolic alterations cause DNA
