Airway hyperresponsiveness (AHR) and exercise-induced bronchoconstriction (EIB) are conditions commonly affecting high-intensity athletes such as competitive swimmers.AHR and EIB in athletes have been well defined, however, studies focusing on...
The impact of cigarette smoke (CS) exposure on the respiratory system can best be captured by evaluating changes in lung function coupled with assessments of morphology and structural composition....
Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure...
Isolated tissue baths, also known as organ chambers, are tools that have been used in the discipline of pharmacology for over 150 years to evaluate tissues contractility and relaxation...
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lungs that has been a major public health problem, and has been the third leading cause of...
The current COVID-19 pandemic has highlighted the need for a rapid development of therapeutic approaches to treat respiratory diseases. Yet, respiratory therapeutic candidates have until now displayed a...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease that is associated with exposure to inhaled irritants such as cigarette smoke and environmental pollutants. COPD is marked by...
There has been incredible scientific effort and progress over the past two years geared at the protection and treatment of COVID-19. In this blog, we will highlight some significant...
Dual vaccination against IL-4 and IL-13 using kinoids (a conjugate vaccine) is one of the therapeutic strategies suggested to neutralize the response induced by this type 2 inflammation. In...
Assessment of airway hyperresponsiveness (AHR) is considered the gold standard in experimental asthma models. In their recent publication, Dr. Steele and colleagues’ objective was to shed light on the...
Asthma is a complex disease, whose principal characteristics include reversible airflow obstruction, airway hyperresponsiveness (AHR), airway inflammation, airway remodeling and mucus hypersecretion. Airway mucus hypersecretion specifically is an important...
Pulmonary Fibrosis (PF) is a type of interstitial lung disease with a poor prognosis and response to current therapies. During the progress of this disease, the build-up of fibrotic...
Acute lung injury (ALI) arises from factors as diverse as endotoxin exposure, chemical assault, acute particulate exposures or mechanical impacts, as seen in ventilator induced lung injury (VILI). ALI...
Longitudinal studies offer a wealth of information, particularly for diseases progression or development studies. In addition, smaller sample sizes are possible to accumulate significant data, as subject assessment is...
Animal models are crucial in advancing our knowledge and understanding of pulmonary diseases. Using alternatives models, such as computer simulations, is simply not advanced enough to elucidate all the...
Work of Breathing & Airway Compliance The latest release of flexiWare (8.2) brings with it the capacity to assess both work of breathing (WOB) and airway compliance, expanding the...
