Development of a Standardized Mouse Model for Nose-Only Inhaled Cannabis
Cannabis is one of the most popular recreational drugs used worldwide. Since the recent legalization of marijuana across several countries and states, there is an increased interest in research
Moving From 3R4F to 1R6F Cigarettes & The Importance of Puff Attributes on Results
In cigarette and e-cigarette studies, the initial composition of the compound being aerosolized, as well as puffing topography has appreciable effects on the puff characteristics and
E-cigarette Vapour Deposition
E-cigarette vapour deposition E-cigarette vapour composition is influenced by a number of factors. Some of which relate to the device physically (battery charge, wattage/temperature control, puffing profile) and others to the e-liquid itself (proportion of propylene glycol and glycerol, amount of nicotine, pH of solution). Standardizing how we study these devices will be key to […]
Pulmonary Hypertension Animal Models
Pulmonary Hypertension Animal Models A lack of validated pulmonary hypertension animal models is the reason why there aren’t enough studies exploring the pathophysiology and therapies for Pulmonary Hypertension (PH). What is pulmonary hypertension? Pulmonary hypertension (PH) is a condition where blood pressure is increased in the arteries of the lungs and is typically associated with […]
Inhalation Exposure Systems for Nicotine Delivery
Inhalation Exposure Systems for Nicotine Delivery Current use of inhalation exposure systems So far only a few studies use computerized inhalation exposure systems for nicotine delivery. Instead many preclinical researchers investigate the effects of nicotine through intraperitoneal injections or oral consumption. Since the effects on the central nervous system (CNS) can depend on the method of administration, […]
Electronic Nicotine Delivery Systems (ENDS)
Electronic Nicotine Delivery Systems (ENDS) Electronic nicotine delivery systems (ENDS) are gaining in popularity in recent years. As a broad overview, an ENDS unit is a battery-powered device which heats up a metal resistive coil to produce an inhalable vapour of an e-liquid, without tobacco combustion. This e-liquid typically consists of Propylene Glycol (PG) and […]
State of Cannabis Research
State of cannabis research Since the recent legalization of recreational cannabis, there is an increased interest in research into both the pulmonary effects of inhaled cannabis, as well as improving our understanding of the endocannabinoid system. The most common method of cannabinoid intake is via inhalation; at which time the lungs receive both biologically active […]