A lack of validated pulmonary hypertension animal models is the reason why there aren’t enough studies exploring the pathophysiology and therapies for Pulmonary Hypertension (PH).
Further, MI mice clearly developed a restrictive respiratory syndrome characterized by a decrease in lung compliance, measured with the flexiVent.
Four weeks after surgery, Dr. Dayeh and her team were able to assess specific lung characteristics in their subjects such as quasi-static compliance, quasi-static elastance, and respiratory system resistance. Since the flexiVent goes beyond traditional resistance and compliance measurements, it helps captures crucial details about the mechanical properties of conducting airways, terminal airways and parenchyma, providing a unique tool to perform a comprehensive assessment of Group 2 PH models and more!
More Publications featuring the flexiVent and other SCIREQ research systems.
They were also invited to examine the effect of increasing the positive end expiratory pressure (PEEP) during ventilation and lung function measurements while exploring the impact on detailed respiratory mechanics parameters before and after the intervention.
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