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Exploring ALI Exposures: From Cell Lines to Endpoints

Air Liquid Interface

Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.

Preclinical Neonate Research

pediatrics neonatology respiratory research equipment

Preclinical Neonate Research Preclinical Pediatrics and Neonate Research Pediatrics and neonatology involves learning more about development and growth through the first stages of life. Early lung development studies investigate the some of the most vulnerable stages of life and must overcome significant experimental challenges when working with small, fragile and uncooperative subjects. The research targets a […]

Insights From SRNT 2021

SCIREQ recently attended this year’s Society For Research On Nicotine and Tobacco (SRNT 2021) Annual Meeting!

E-cigarette Vapour Deposition

E-cigarette vapour deposition E-cigarette vapour composition is influenced by a number of factors. Some of which relate to the device physically (battery charge, wattage/temperature control, puffing profile) and others to the e-liquid itself (proportion of propylene glycol and glycerol, amount of nicotine, pH of solution). Standardizing how we study these devices will be key to […]

Pulmonary Hypertension Animal Models

Pulmonary Hypertension Animal Models A lack of validated pulmonary hypertension animal models is the reason why there aren’t enough studies exploring the pathophysiology and therapies for Pulmonary Hypertension (PH).   What is pulmonary hypertension? Pulmonary hypertension (PH) is a condition where blood pressure is increased in the arteries of the lungs and is typically associated with […]

Inhalation Exposure Systems for Nicotine Delivery

Inhalation Exposure Systems for Nicotine Delivery Current use of inhalation exposure systems:  So far only a few studies use computerized inhalation exposure systems for nicotine delivery. Instead many preclinical researchers investigate the effects of nicotine through intraperitoneal injections or oral consumption. Since the effects on the central nervous system (CNS) can depend on the method of administration, […]

Electronic Nicotine Delivery Systems (ENDS)

Electronic Nicotine Delivery Systems (ENDS) Electronic nicotine delivery systems (ENDS) are gaining in popularity in recent years. As a broad overview, an ENDS unit is a battery-powered device which heats up a metal resistive coil to produce an inhalable vapour of an e-liquid, without tobacco combustion. This e-liquid typically consists of Propylene Glycol (PG) and […]