So far only a few studies use computerized inhalation exposure systems for nicotine delivery. Instead many preclinical researchers investigate the effects of nicotine through intraperitoneal injections or oral consumption. Since the effects on the central nervous system (CNS) can depend on the method of administration, traditional methods of nicotine delivery such as cigarette smoke and e-cigarette vapor inhalation, provide relevant translational outcomes for clinical investigations.
Dr. Alasmari and Dr. Crotty Alexander from the College of Pharmacy and Pharmaceutical Sciences of the University of Toledo and the Pulmonary and Critical Care Section of the San Diego Health Care System Institutions investigated the delivery of e-cigarette vapor and tobacco smoke through computerized machines. In addition to that, they compared the efficiency and practical applicability of the inExpose system to other nicotine inhalation systems.
Due to its precise control over the exposure, the inExpose allows researchers to finely-tune experiments to mimic real-world conditions providing relevant and practical animal models, which can be reproduced by collaborators globally.
¹Alasmari, Fawaz, et al. “A computerized exposure system for animal models to optimize nicotine delivery into the brain through inhalation of electronic cigarette vapors or cigarette smoke.” Saudi pharmaceutical journal (2018).
E-Cigarette vapour composition is influenced by a number of factors and standardizing how we study these devices will be key to understanding their impact.
Welcome to SCIREQ’s knowledge center. You can find everything from software registration to document downloads to complete list of SCIREQ publications in this section. Everything you need to get the most out of your SCIREQ system.