Let’s Talk About Impedance
The current state-of-the-art in pre-clinical lung function measurements is the evaluation of the mechanical properties of the respiratory system using FOT.
Advantages Across Mice Strains In Respiratory Research
Mice strain can have an important impact on research, as certain strains are better suited to some applications than others.
Lung Function in Conscious Subjects
Discover how to accurately measure lung function in conscious subjects using WBP, HOP, and DCP. Learn why EF50 is a crucial indicator for airway response and respiratory safety pharmacology.
The Relationship Between e-Cigarette Exposure, Sex Steroids, and COVID-19
Throughout the global COVID-19 pandemic, there has been a noticeably higher mortality rate in males compared to females. Though the mechanism that causes this remains unknown, Dr. Sharma and Dr. Zeki hypothesize
Translational Preclinical Models of COVID-19
In May 2021, SCIREQ had the pleasure of hosting a virtual panel discussion with leading preclinical infectious disease researchers focusing on Preclinical Models of COVID-19.
Diabetes associated fibrosis- in vivo functional assessment
Kumar et al. (2020) recently published a novel manuscript that combined work on cellular and mouse models shows that hyperglycemic conditions and the resultant metabolic alterations cause DNA
The use of the flexiVent FX in testing inhaled β agonists during an allergic model bronchoconstrictor challenge
The forced oscillation technique (FOT) using the flexiVent has been the gold standard for pulmonary function tests (PFTs) in small animal in vivo studies for many years.
Hypersensitive Response in Asthmatic Guinea Pigs Following House Dust Mite Exposure
Due to the wide variety of strains available and ease of procurement and care, the mouse dominates in vivo pre-clinical research. Although a robust model, important divergences from human physiology makes
Moving From 3R4F to 1R6F Cigarettes & The Importance of Puff Attributes on Results
In cigarette and e-cigarette studies, the initial composition of the compound being aerosolized, as well as puffing topography has appreciable effects on the puff characteristics and
Bronchoalveolar Lavage (Bal) Technique
In a pre-clinical setting, respiratory mechanics measurements provide in-depth understanding into the lung’s function, structures and volumes.