Mice strain can have an important impact on research, as certain strains are better suited to some applications than others. Three main strains of mice (A/J1, BALB/c2, C57B/63) are typically studied in respiratory research, using the SCIREQ flexiVent as a platform to assess respiratory mechanics across applications.
A/J mice are most commonly used for cancer and carcinogen testing because of their high susceptibility to carcinogen-induced tumours. In a respiratory context, these mice have airways that are spontaneously hyperresponsive to bronchoconstricting agents and develop cigarette smoke-induced emphysema more quickly than other strains, particularly the AKR/J mice.
BALB/c mice are frequently used for a variety of immunological studies, in part because they demonstrate TH2-biased immune responses. These mice are particularly well known for producing monoclonal antibodies.
C57BL/6 mice are the most commonly used strain due to their fully known genome and transgenic possibilities. These mice are used as a general purpose and background strain, making them widely published and easy to compare results across studies.
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