CX3CL1/CX3CR1 Signaling Pathway in Fungal-Associated Allergic Asthma: Good or Bad? The Devil is in the Method
Assessment of airway hyperresponsiveness (AHR) is considered the gold standard in experimental asthma models. In their recent publication, Dr. Steele and colleagues’ objective was to shed light on the immunopathogenic role of CX3CL1/Fractalkine because of its elevated levels in fungal-sensitized asthmatics.
Mucolytic Treatment in Allergic Airway Disease
Asthma is a complex disease, whose principal characteristics include reversible airflow obstruction, airway hyperresponsiveness (AHR), airway inflammation, airway remodeling and mucus hypersecretion. Airway mucus hypersecretion specifically is an important and dangerous pathophysiological manifestation of asthma.
Longitudinal Micro‑CT Derived Biomarkers in Silicosis Fibrosis Model
Pulmonary Fibrosis (PF) is a type of interstitial lung disease with a poor prognosis and response to current therapies. During the progress of this disease, the build-up of fibrotic tissue leads to an overall rigidity of lung architecture, leading to a gradual decline in lung function.
Visualizing Lung Physiology in Response to Chemical and Mechanical Assaults
Acute lung injury (ALI) arises from factors as diverse as endotoxin exposure, chemical assault, acute particulate exposures or mechanical impacts, as seen in ventilator induced lung injury (VILI). ALI and VILI studies push the understanding of both fundamental breathing mechanics and general lung physiology to describe how damage occurs in the hopes of mitigating of damage.
Longitudinal Studies with SCIREQ Systems
Longitudinal studies offer a wealth of information, particularly for diseases progression or development studies. In addition, smaller sample sizes are possible to accumulate significant data, as subject assessment is possible at multiple time points.
Animal Models for Pulmonary Diseases
Animal models are crucial in advancing our knowledge and understanding of pulmonary diseases. Using alternatives models, such as computer simulations, is simply not advanced enough to elucidate all the biological mechanisms inside a living creature.
Work of Breathing & Airway Compliance
The latest release of flexiWare (8.2) brings with it the capacity to assess both work of breathing (WOB) and airway compliance, expanding the comprehensive array of pulmonary assessments possible with the flexiVent system.
Asthma – From Mouse To Man
Asthma is a complex heterogeneous disease whose features have not been completely depicted by any single mouse disease model. In preclinical (in vivo) research, careful considerations should be given to the model employed, its phenotype, as well as the measured outcomes.
The Usefulness Of Recruitment Manoeuvres
Atelectasis or airway closure spontaneously develops following anaesthesia and mechanical ventilation. This progressive loss in lung volume can have a significant impact on the subject’s
Let’s Talk About Impedance
The current state-of-the-art in pre-clinical lung function measurements is the evaluation of the mechanical properties of the respiratory system using FOT.