To Open or Close the Lungs – That Is the Question!
To Open or Close the Lungs – That Is the Question! Although often necessary, mechanical ventilation of small animals during pulmonary measurements can lead to both acute and chronic damage to their lungs, also known as ventilator-induced lung injury (VILI). The injury happens as a result of the frequent opening and closing of alveolar air […]
Longitudinal Studies With The flexiVent to Acquire Lung Mechanics
When developing an appropriate protocol to assess respiratory mechanics, there is a trade-off between accuracy of the measurements and the invasiveness of the technique. The flexiVent favours an invasive technique, producing results that are unparalleled in accuracy.
Empower Yourself
Attending a training such as the Phenotyping Mice Models of Human Lung Disease organized by the Jackson Laboratory is a great way to advance skillsets or simply get started in the field of respiratory research. It represents a wonderful opportunity for researchers of all stages to learn and network in a structured yet informal environment. The uniqueness of the event lies in the roundness of the approach, which combines theoretical sessions and practical experience in all topics.
E-cigarette Vapour Deposition
E-cigarette vapour composition is influenced by a number of factors. Some of which relate to the device physically (battery charge, wattage/temperature control, puffing profile) and others to the e-liquid itself (proportion of propylene glycol and glycerol, amount of nicotine, pH of solution). Standardizing how we study these devices will be key to understanding their impact.
Pulmonary Hypertension Animal Models
A lack of validated pulmonary hypertension animal models is the reason why there aren’t enough studies exploring the pathophysiology and therapies for Pulmonary Hypertension (PH).
Reproducible e-Cigarettes Exposure Environments
Studies addressing the potential risks associated with electronic cigarette (e-cig) usage are urgently needed, given their rising use and popularity, especially in youth. Coordinated efforts are required to tackle the challenge of addressing key scientific questions, as there is a diversity of devices and e-liquid formulations that exists, as well as various ways in which the aerosol can be generated.
Whole Body Plethysmograph – vivoFlow launches at EB 2019
During the Experimental Biology Meeting that took place in Orlando from April 6-9, 2019, SCIREQ launched the vivoFlow – WBP (Whole Body Plethysmograph Chamber). The vivoFlow is fully compatible with our current system and has several design features which both improve data quality and usability.
Circadian Rhythm Effects Lung Function
The circadian rhythm regulates many physiological parameters including lung function, immune responses, and cardiopulmonary function. The master circadian pacemaker is located in the anterior of the hypothalamus, also called the suprachiasmatic nuclei (SCN). The SCN receives inputs from environmental cues, such as light and temperature and modulates downstream vital biological functions in an oscillatory fashion.
Inhalation Exposure Systems for Nicotine Delivery
Since the effects on the central nervous system (CNS) can depend on the method of administration, traditional methods of nicotine delivery such as cigarette smoke and e-cigarette vapor inhalation, provide relevant translational outcomes for clinical investigations.
Obese Mice Study Proves to Use the Ideal Weight
When working with obese mice, what weight to use when performing flexiVent measurements?