vivoFlow for Preclinical SARS-CoV-2 Hamster Studies
As in humans, the Angiotensin I Converting Enzyme 2 (ACE2) receptors of hamsters naturally permit binding of the SARS-CoV-2 virus spike protein. This suggests that hamsters are an important
Development of a Standardized Mouse Model for Nose-Only Inhaled Cannabis
Cannabis is one of the most popular recreational drugs used worldwide. Since the recent legalization of marijuana across several countries and states, there is an increased interest in research
Moving From 3R4F to 1R6F Cigarettes & The Importance of Puff Attributes on Results
In cigarette and e-cigarette studies, the initial composition of the compound being aerosolized, as well as puffing topography has appreciable effects on the puff characteristics and
Bronchoalveolar Lavage (Bal) Technique
In a pre-clinical setting, respiratory mechanics measurements provide in-depth understanding into the lung’s function, structures and volumes.
COVID-19, Vaping, and EVALI
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Animal Models of Rett Syndrome
Rett syndrome is a severe neurodevelopmental disease resulting from a loss of function mutation in MeCP2; an epigenetic modulator of transcription regulation
Refined Study Design with Spirometry
Spirometry is a widely known clinical pulmonary test measuring volumes and flows expired by patients that is used to confirm a diagnostic of respiratory disease or follow treatment. SCIREQ’s flexiVent’s offers an analogous test for preclinical research with its Negative Pressure Forced Expiration (NPFE) extension.
inExpose featured in Nature publication
Congratulations to Dr. Blackwell’s team at Vanderbilt University who recently published in Nature Communications1 with the inExpose!
As you may know, chronic obstructive pulmonary disease (COPD) is characterized by obstruction in airflow, chronic inflammation, and destruction of the alveolar tissue. This group from Vanderbilt University hypothesized that secretory immunoglobulin A (SIgA) deficiency contributes to chronic airway inflammation and COPD disease progression.
FlexiVent – Used in Recent Pulmonary Fibrosis Research
Pulmonary fibrosis describes a condition in which the normal lung anatomy is replaced by a process of active remodeling, deposition of extracellular matrix and dramatic changes in the phenotype of both fibroblasts and alveolar epithelial cells. This condition can be idiopathic, as in idiopathic pulmonary fibrosis (IPF), or secondary to genetic disorders, autoimmune disorders or exposure to environmental toxins, chemical warfare, drugs, foreign antigens or radiation
Function Follows Form and Form Follows Function
The flexiVent makes assessing mechanical properties of the lung a relatively simple undertaking. However, understanding the underlying physiological processes and mathematical modelling can be daunting. A background in pulmonary structure, function, and of the forces at play within the system are key to making the most of the provided outcomes.