The Usefulness Of Recruitment Manoeuvres
Atelectasis or airway closure spontaneously develops following anaesthesia and mechanical ventilation. This progressive loss in lung volume can have a significant impact on the subject’s
Let’s Talk About Impedance
The current state-of-the-art in pre-clinical lung function measurements is the evaluation of the mechanical properties of the respiratory system using FOT.
Advantages Across Mice Strains In Respiratory Research
Mice strain can have an important impact on research, as certain strains are better suited to some applications than others.
The Relationship Between e-Cigarette Exposure, Sex Steroids, and COVID-19
Throughout the global COVID-19 pandemic, there has been a noticeably higher mortality rate in males compared to females. Though the mechanism that causes this remains unknown, Dr. Sharma and Dr. Zeki hypothesize
Translational Preclinical Models of COVID-19
In May 2021, SCIREQ had the pleasure of hosting a virtual panel discussion with leading preclinical infectious disease researchers focusing on Preclinical Models of COVID-19.
Diabetes associated fibrosis- in vivo functional assessment
Kumar et al. (2020) recently published a novel manuscript that combined work on cellular and mouse models shows that hyperglycemic conditions and the resultant metabolic alterations cause DNA
New Insights From Keystone eSymposia- COVID-19 One Year Later
This February, Keystone held a virtual conference that discussed SARS-CoV-2 transmissibility, immune response, and updates on vaccines and treatments.
The use of the flexiVent FX in testing inhaled β agonists during an allergic model bronchoconstrictor challenge
The forced oscillation technique (FOT) using the flexiVent has been the gold standard for pulmonary function tests (PFTs) in small animal in vivo studies for many years.
Hypersensitive Response in Asthmatic Guinea Pigs Following House Dust Mite Exposure
Due to the wide variety of strains available and ease of procurement and care, the mouse dominates in vivo pre-clinical research. Although a robust model, important divergences from human physiology makes
vivoFlow for Preclinical SARS-CoV-2 Hamster Studies
As in humans, the Angiotensin I Converting Enzyme 2 (ACE2) receptors of hamsters naturally permit binding of the SARS-CoV-2 virus spike protein. This suggests that hamsters are an important