The use of the flexiVent FX in testing inhaled β agonists during an allergic model bronchoconstrictor challenge
The forced oscillation technique (FOT) using the flexiVent has been the gold standard for pulmonary function tests (PFTs) in small animal in vivo studies for many years.
Hypersensitive Response in Asthmatic Guinea Pigs Following House Dust Mite Exposure
Due to the wide variety of strains available and ease of procurement and care, the mouse dominates in vivo pre-clinical research. Although a robust model, important divergences from human physiology makes
vivoFlow for Preclinical SARS-CoV-2 Hamster Studies
As in humans, the Angiotensin I Converting Enzyme 2 (ACE2) receptors of hamsters naturally permit binding of the SARS-CoV-2 virus spike protein. This suggests that hamsters are an important
Development of a Standardized Mouse Model for Nose-Only Inhaled Cannabis
Cannabis is one of the most popular recreational drugs used worldwide. Since the recent legalization of marijuana across several countries and states, there is an increased interest in research
Moving From 3R4F to 1R6F Cigarettes & The Importance of Puff Attributes on Results
In cigarette and e-cigarette studies, the initial composition of the compound being aerosolized, as well as puffing topography has appreciable effects on the puff characteristics and
Bronchoalveolar Lavage (Bal) Technique
In a pre-clinical setting, respiratory mechanics measurements provide in-depth understanding into the lung’s function, structures and volumes.
COVID-19, Vaping, and EVALI
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Animal Models of Rett Syndrome
Rett syndrome is a severe neurodevelopmental disease resulting from a loss of function mutation in MeCP2; an epigenetic modulator of transcription regulation
Refined Study Design with Spirometry
Spirometry is a widely known clinical pulmonary test measuring volumes and flows expired by patients that is used to confirm a diagnostic of respiratory disease or follow treatment. SCIREQ’s flexiVent’s offers an analogous test for preclinical research with its Negative Pressure Forced Expiration (NPFE) extension.
Longitudinal Studies With The flexiVent to Acquire Lung Mechanics
When developing an appropriate protocol to assess respiratory mechanics, there is a trade-off between accuracy of the measurements and the invasiveness of the technique. The flexiVent favours an invasive technique, producing results that are unparalleled in accuracy.