New insights from AITox 2020!
The AITox seminars this year were quite interesting and informative, the organizers did a great job pivoting into the virtual world! If you missed the opportunity to attend, here are some highlights and what we learned.
Dynamic in-vivo imaging
Airway hyperresponsiveness (AHR) is a very complex relationship between smooth muscle and localized inflammation with little known about the exact physiology behind a response.
Moving From 3R4F to 1R6F Cigarettes & The Importance of Puff Attributes on Results
In cigarette and e-cigarette studies, the initial composition of the compound being aerosolized, as well as puffing topography has appreciable effects on the puff characteristics and
Bronchoalveolar Lavage (Bal) Technique
In a pre-clinical setting, respiratory mechanics measurements provide in-depth understanding into the lung’s function, structures and volumes.
COVID-19, Vaping, and EVALI
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Providing Detailed Insight Into Lung Inflammatory Responses
The emergence of novel zoonotic outbreaks such as COVID-19 continue to result in high mortality rates, as seen in previous epidemics (i.e SARS & MERS).
Animal Models of Rett Syndrome
Rett syndrome is a severe neurodevelopmental disease resulting from a loss of function mutation in MeCP2; an epigenetic modulator of transcription regulation
The Lung Epithelial Protein PDIA3’s Role In Airway Mechanics During Influenza Infection
The Lung Epithelial Protein PDIA3’s Role In Airway Mechanics During Influenza Infection Protein disulfide isomerases (PDIs) are a family of chaperone enzymes within the eukaryotic endoplasmic reticulum that facilitate creation of disulfide (-S-S-) bonds in proteins. PDIA3 is a PDI which has been found to interact with influenza virus A hemagglutinin (IHA), a protein found […]
Refined Study Design with Spirometry
Refined Preclinical Study Design with Spirometry Spirometry is a widely known clinical pulmonary test measuring volumes and flows expired by patients that is used to confirm a diagnostic of respiratory disease or follow treatment. SCIREQ’s flexiVent’s offers an analogous test for preclinical research with its Negative Pressure Forced Expiration (NPFE) extension. By exposing the subject’s airway […]
FlexiVent – Used in Recent Pulmonary Fibrosis Research
FlexiVent – Used in Recent Pulmonary Fibrosis Research Pulmonary fibrosis describes a condition in which the normal lung anatomy is replaced by a process of active remodeling, deposition of extracellular matrix and dramatic changes in the phenotype of both fibroblasts and alveolar epithelial cells. This condition can be idiopathic, as in idiopathic pulmonary fibrosis (IPF), […]