Precision Particles for Persistent Asthma

A promising solution for Asthma: an innovative dry powder for inhalation (DPI) designed for controlled release and prolonged lung retention.

The Role Of Setmelanotide In Improving Hypercapnic Chemosensitivity And Weight Loss In Male Mice

Obesity is a significant contributor to respiratory disorders such as Obesity Hypoventilation Syndrome (OHS) and sleep apnea, both of which are characterized by reduced respiratory chemosensitivity. These conditions not only impair breathing but also exacerbate the health risks associated with obesity.

Advanced Respiratory And Multi-Parameter Monitoring In Preclinical Models Of Rett Syndrome

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in the MECP2 gene, leading to various symptoms, including cognitive impairment, motor dysfunction, and significant respiratory abnormalities.

Validating The Bleo-Induced Mouse Model For Drug Discovery

Discover how validating the BLEO-induced mouse model using advanced vivoFlow and flexiVent lung function testing is accelerating preclinical drug discovery for Idiopathic Pulmonary Fibrosis (IPF).

The Role of Orexin Neurons in Altered Respiratory Responses and SUDEP Risk

Sudden Unexpected Death in Epilepsy (SUDEP) remains a critical concern in epilepsy management, with the underlying mechanisms still not fully understood.

Assessing the Safety of Warfare Nerve Agent Antidotes Using Dual-Chamber Plethysmography

Despite international treaties, the usage of chemical weapons is still a concern nowadays. This article highlights a study using Dual-chamber plethysmography for the determination of the NOAEL dose of an oxime, for the treatment of organophosphorus-nerve agents poisoning.

The Potential Of WNT/Β-Catenin Modulation in Treating Pulmonary Fibrosis

Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), represents a significant challenge in healthcare due to its detrimental impact on lung function and limited treatment options.

CSX-1004: A Promising Solution in the Fight Against the Fentanyl Crisis

In this blog, we will explore the groundbreaking preclinical work on CSX-1004, a fully human monoclonal antibody with exceptional affinity for fentanyl and related analogs, offering hope in the battle against opioid overdose deaths.

The Role of Chx10 Neurons in Global Motor Arrest

In the intricate web of neural circuits that guide our every move, a recent study has shed light on a fascinating phenomenon: the arrest of ongoing movements

Combining Telemetry & Plethysmography: Powerful Insight Into the Control of Breathing

Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.