Chronic Intermittent Hypoxia and Hypertension
Obstructive sleep apnea syndrome (OSA) is a complete or partial airway obstruction that can cause significant physiological disturbances with various clinical impacts such as snoring, nocturnal awakening, or daytime sleepiness.
Ultrapotent Miniproteins Protect Against SARS-CoV-2 Lung Inflammation and Pathology
Ultrapotent Miniproteins Protect Against SARS-CoV-2 Lung Inflammation and Pathology A recent study published in Cell Host & Microbe by Dr. Michael Diamond’s group at the University of Washington investigated ultrapotent miniproteins (LCB1) as a novel means of targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These specific miniproteins target the Receptor Binding Domain (RBD) […]
Asthma – From Mouse To Man
Asthma – From Mouse To Man “The assessment of lung function endpoints used in preclinical drug testing may hold the key to translation of drug efficacy from mouse to man¹.” Bench-to-bedside Mouse models have been and continue to be of invaluable importance in asthma research, for the elucidation of key disease pathways as well as […]
Diabetes associated fibrosis- in vivo functional assessment
Kumar et al. (2020) recently published a novel manuscript that combined work on cellular and mouse models shows that hyperglycemic conditions and the resultant metabolic alterations cause DNA
COVID-19, Vaping, and EVALI
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Providing Detailed Insight Into Lung Inflammatory Responses
The emergence of novel zoonotic outbreaks such as COVID-19 continue to result in high mortality rates, as seen in previous epidemics (i.e SARS & MERS).
Animal Models of Rett Syndrome
Rett syndrome is a severe neurodevelopmental disease resulting from a loss of function mutation in MeCP2; an epigenetic modulator of transcription regulation
Reproducible e-Cigarettes Exposure Environments
Reproducible E-cigarettes Exposure Environments Studies addressing the potential risks associated with electronic cigarette (e-cig) usage are urgently needed, given their rising use and popularity, especially in youth. Coordinated efforts are required to tackle the challenge of addressing key scientific questions, as there is a diversity of devices and e-liquid formulations that exists, as well as […]
Alpha-1 Antitrypsin (AAT) Deficiency
Alpha-1 Antitrypsin (AAT) Deficiency Alpha-1 antitrypsin (AAT) deficiency is an inherited disorder, most prevalent in populations of European ancestry, and is underdiagnosed. It results from mutations in the SERPINA1 gene, leading to either a reduced level or function of the AAT protein. AAT deficiency results a variety of health issues, particularly predisposition to the development of liver […]
Whole Body Plethysmograph – vivoFlow launches at EB 2019
Whole Body Plethysmograph – vivoFlow Launches at EB 2019 SCIREQ is preparing for the upcoming Experimental Biology Meeting that will take place in Orlando from April 6-9, 2019. At this meeting we launch our latest development: the vivoFlow – WBP (Whole Body Plethysmograph Chamber). The vivoFlow is fully compatible with our current system and has several design features which both […]