Asthma – From Mouse To Man
Asthma is a complex heterogeneous disease whose features have not been completely depicted by any single mouse disease model. In preclinical (in vivo) research, careful considerations should be given to the model employed, its phenotype, as well as the measured outcomes.
Diabetes associated fibrosis- in vivo functional assessment
Kumar et al. (2020) recently published a novel manuscript that combined work on cellular and mouse models shows that hyperglycemic conditions and the resultant metabolic alterations cause DNA
COVID-19, Vaping, and EVALI
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Animal Models of Rett Syndrome
Rett syndrome is a severe neurodevelopmental disease resulting from a loss of function mutation in MeCP2; an epigenetic modulator of transcription regulation
Reproducible e-Cigarettes Exposure Environments
Studies addressing the potential risks associated with electronic cigarette (e-cig) usage are urgently needed, given their rising use and popularity, especially in youth. Coordinated efforts are required to tackle the challenge of addressing key scientific questions, as there is a diversity of devices and e-liquid formulations that exists, as well as various ways in which the aerosol can be generated.
Whole Body Plethysmograph – vivoFlow launches at EB 2019
During the Experimental Biology Meeting that took place in Orlando from April 6-9, 2019, SCIREQ launched the vivoFlow – WBP (Whole Body Plethysmograph Chamber). The vivoFlow is fully compatible with our current system and has several design features which both improve data quality and usability.
Circadian Rhythm Effects Lung Function
The circadian rhythm regulates many physiological parameters including lung function, immune responses, and cardiopulmonary function. The master circadian pacemaker is located in the anterior of the hypothalamus, also called the suprachiasmatic nuclei (SCN). The SCN receives inputs from environmental cues, such as light and temperature and modulates downstream vital biological functions in an oscillatory fashion.