Ultrapotent Miniproteins Protect Against SARS-CoV-2 Lung Inflammation and Pathology A recent study published in Cell Host & Microbe by Dr. Michael Diamond’s group at the University of Washington investigated ultrapotent miniproteins (LCB1) as a novel means of targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These specific miniproteins target the Receptor Binding Domain (RBD) […]
Asthma – From Mouse To Man “The assessment of lung function endpoints used in preclinical drug testing may hold the key to translation of drug efficacy from mouse to man¹.” Bench-to-bedside Mouse models have been and continue to be of invaluable importance in asthma research, for the elucidation of key disease pathways as well as […]
Kumar et al. (2020) recently published a novel manuscript that combined work on cellular and mouse models shows that hyperglycemic conditions and the resultant metabolic alterations cause DNA
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
The emergence of novel zoonotic outbreaks such as COVID-19 continue to result in high mortality rates, as seen in previous epidemics (i.e SARS & MERS).
Rett syndrome is a severe neurodevelopmental disease resulting from a loss of function mutation in MeCP2; an epigenetic modulator of transcription regulation
Reproducible E-cigarettes Exposure Environments Studies addressing the potential risks associated with electronic cigarette (e-cig) usage are urgently needed, given their rising use and popularity, especially in youth. Coordinated efforts are required to tackle the challenge of addressing key scientific questions, as there is a diversity of devices and e-liquid formulations that exists, as well as […]
Alpha-1 Antitrypsin (AAT) Deficiency Alpha-1 antitrypsin (AAT) deficiency is an inherited disorder, most prevalent in populations of European ancestry, and is underdiagnosed. It results from mutations in the SERPINA1 gene, leading to either a reduced level or function of the AAT protein. AAT deficiency results a variety of health issues, particularly predisposition to the development of liver […]
Whole Body Plethysmograph – vivoFlow Launches at EB 2019 SCIREQ is preparing for the upcoming Experimental Biology Meeting that will take place in Orlando from April 6-9, 2019. At this meeting we launch our latest development: the vivoFlow – WBP (Whole Body Plethysmograph Chamber). The vivoFlow is fully compatible with our current system and has several design features which both […]
Circadian Rhythm Effects Lung Function Circadian rhythm changes can affect lung function, introducing susceptibility to infection and other adverse effects on health and disease. What does the circadian rhythm do? The circadian rhythm regulates many physiological parameters including lung function, immune responses, and cardiopulmonary function. The master circadian pacemaker is located in the anterior of […]