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Respiration & Neural Dynamics in Odor Fear Learning

The ability to time intervals is critical for fundamental animal behaviors such as anticipating rewarding or aversive events. However, the neurobiological basis of interval timing in Pavlovian associative learning is poorly understood.

Cigarette Smoke Negatively Affects Pulmonary Structure and Function in an Apoe

The impact of cigarette smoke (CS) exposure on the respiratory system can best be captured by evaluating changes in lung function coupled with assessments of morphology and structural composition. These measurements are both quantitative and can capture the extent of disease severity such as degree, pattern, and location of tissue destruction.

New Mouse Handling Recommendations For Improving Animal and Handler Well-being

All research model systems have unique strengths and challenges regarding the generalizability of data to other systems. Pre-clinical researchers attempt to describe and interact with human clinical phenotypes using animal models. These models allow manipulation and testing of scientific hypotheses within the context of a complex system, providing insights that may be impossible using in vivo methods or within the constraints of clinical interventions.

Longitudinal Micro‑CT Derived Biomarkers in Silicosis Fibrosis Model

Pulmonary Fibrosis (PF) is a type of interstitial lung disease with a poor prognosis and response to current therapies. During the progress of this disease, the build-up of fibrotic tissue leads to an overall rigidity of lung architecture, leading to a gradual decline in lung function.

Visualizing Lung Physiology in Response to Chemical and Mechanical Assaults

Acute lung injury (ALI) arises from factors as diverse as endotoxin exposure, chemical assault, acute particulate exposures or mechanical impacts, as seen in ventilator induced lung injury (VILI). ALI and VILI studies push the understanding of both fundamental breathing mechanics and general lung physiology to describe how damage occurs in the hopes of mitigating of damage.

Animal Models for Pulmonary Diseases

Animal models are crucial in advancing our knowledge and understanding of pulmonary diseases. Using alternatives models, such as computer simulations, is simply not advanced enough to elucidate all the biological mechanisms inside a living creature.

Preclinical Neonate Research

pediatrics neonatology respiratory research equipment

Preclinical Neonate Research Preclinical Pediatrics and Neonate Research Pediatrics and neonatology involves learning more about development and growth through the first stages of life. Early lung development studies investigate the some of the most vulnerable stages of life and must overcome significant experimental challenges when working with small, fragile and uncooperative subjects. The research targets a […]

Asthma – From Mouse To Man

Asthma - From Mouse To Man

Asthma – From Mouse To Man “The assessment of lung function endpoints used in preclinical drug testing may hold the key to translation of drug efficacy from mouse to man¹.” Bench-to-bedside Mouse models have been and continue to be of invaluable importance in asthma research, for the elucidation of key disease pathways as well as […]

Translational Preclinical Models of COVID-19

In May 2021, SCIREQ had the pleasure of hosting a virtual panel discussion with leading preclinical infectious disease researchers focusing on Preclinical Models of COVID-19.