Reducing Variability in Lung Slice Analysis
A recent publication by Boucher et al (2024) streamlines this process of quantifying airway constriction in Precision Cut Lung Slices (PCLS) by using the new physioLens automated solution for physiology and image analysis. This new solution enables researchers to conduct high-throughput screening of airway constriction with unprecedented precision and efficiency.
Assessing the Safety of Warfare Nerve Agent Antidotes Using Dual-Chamber Plethysmography
Despite international treaties, the usage of chemical weapons is still a concern nowadays. This article highlights a study using Dual-chamber plethysmography for the determination of the NOAEL dose of an oxime, for the treatment of organophosphorus-nerve agents poisoning.
SoftRestraints for Inhalation Exposure Studies
Any restraining device used in an inhalation exposure set-up will be, by definition, restricting the subject’s ability to move. SCIREQ’s SoftRestraints are designed to minimize some of these important effects typical restraints have on the subject.
In Vitro Inhalation Testing: Revolutionizing Inhalation Product Safety
Discover how the expoCube was used in a study to understand the possible adverse acute inhalation effects of aerosols on consumer safety.
CSX-1004: A Promising Solution in the Fight Against the Fentanyl Crisis
In this blog, we will explore the groundbreaking preclinical work on CSX-1004, a fully human monoclonal antibody with exceptional affinity for fentanyl and related analogs, offering hope in the battle against opioid overdose deaths.
The Role of Chx10 Neurons in Global Motor Arrest
In the intricate web of neural circuits that guide our every move, a recent study has shed light on a fascinating phenomenon: the arrest of ongoing movements
PCLS: Unraveling the Intricacies of Asthma Research
In the quest for better treatment options, precision cut lung slices (PCLS) have emerged as a cutting-edge tool in preclinical asthma research
FEV Measurements in Preclinical Models of Respiratory Disease
As researchers strive to bridge the gap between preclinical investigations and clinical outcomes, the accurate assessment of Forced Expired Volume (FEV) and Forced Vital Capacity (FVC) emerges as a cornerstone for establishing translational relevance.
Combining Telemetry & Plethysmography: Powerful Insight Into the Control of Breathing
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
Plethysmography for the assessment of opioid-induced respiratory depression
Opioid-related addiction, overdose and death is a widespread public health crisis. A recent paper provides a model example of the how plethysmography can be used to assess ventilatory behavior changes that occur with opioid administration.