The flexiVent’s unique ability to measure central vs. peripheral airways resistance, combined with a delivered dose estimator and an automated dose-response feature permits unique and novel insights into inflammatory responses and evolution of lung function throughout the progression of infectious respiratory diseases.
As respiratory infection induces airway hyperresponsiveness and mucus hypersecretion, the flexiVent can be used to both deliver aerosol challenges to a subject’s lungs and follow the developing bronchoconstriction through automated data collection. The software calculates and displays an estimate of the dose delivered to the subject’s airway opening. Furthermore, detailed dose-response curves demonstrating airway hyperresponsiveness are computed and graphed in real-time. Learn what Dr. Davis, a researcher at the forefront of pulmonary viral infection research, has to say about working with the flexiVent.
In preclinical disease models, the analysis of ventilatory patterns in conscious subjects could prove to be useful for continuous tracking of the progression of infectious respiratory diseases over time.
Plethysmography, as a non-invasive technique, offers a powerful means of rapidly screening subjects based on changes in ventilatory parameters (e.g. breathing frequency, tidal volume, peak inspiratory or expiratory flows) following respiratory infection. Additionally, enhanced pause (Penh) is an indicator of airway obstruction and morbidity, that quantifies changes in the shape of the breathing waveform. Events such as coughing and apneas can also be detected and monitored.
Dr. Ian Davis is a Principal Investigator and Professor at The Ohio State University. Research in the Davis lab is focused on the effects of influenza A infections on alveolar epithelial cell function in a mouse model of influenza induced ARDS. Learn more about his lab and research in this interview!
There has been much progress in identifying relevant in vitro and in vivo modelling for SARS-CoV-2 vaccine development and therapeutic intervention. Learn more about the current research, as preclinical infectious disease researchers delve into the advantages and disadvantages of various SARS-CoV-2 animal models.
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