Techniques for imaging the lung have been successfully implemented and validated in humans. These techniques are also of great interest in a preclinical setting, as they provide valuable information on the lung structure and function in a non-invasive manner. This qualitative and quantitative assessment of the lung can therefore be performed in a repetitive manner in order to establish a diagnosis, follow lung growth or disease progression over time, quantify the amount of change or assess the impact of a given therapeutic intervention.
ELIMINATING MOTION ARTIFACTS
At the preclinical level, the acquisition of high resolution images is technically more challenging due to the small size of the structures and the constant motion of the respiratory system which produces artifacts. The programmable aspect of the flexiVent allows advanced gating techniques by enabling image capture during breath hold, which greatly increases image contrast and resolution. Other advantages of this gating technique include the ability to perform respiratory mechanics measurements during the imaging session to complement the study or help image interpretation.
The flexiVent gating protocols could equally be applied to capture high resolution images of other thoracic structures, including cardiac structures, which can also be affected by the motion artifacts of the respiratory system.
- Tomographic in vivo microscopy for the study of lung physiology at the alveolar level – Lovric, G. et al. Scientific Reports. p. 12545. 2017.
- Dynamic in vivo chest x-ray dark-field imaging in mice – Dierolf, M. et al. IEEE Transactions on Medical Imaging, 0062(c), pp. 1–1. 2018.
- Autofluorescence multiphoton microscopy for visualization of tissue morphology and cellular dynamics in murine and human airways – Kretschmer, S. et al. Laboratory Investigation; a Journal of Technical Methods and Pathology. p. 918. 2016.
- In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source – Gradl, R. et al. Scientific Reports. p. 6788. 2018.
- Visualizing treatment delivery and deposition in mouse lungs using in vivo x-ray imaging – Gradl, R. et al. Journal of Controlled Release. 2019.
- Three-Dimensional Quantitative Co-Mapping of Pulmonary Morphology and Nanoparticle Distribution with Cellular Resolution in Nondissected Murine Lungs – Yang, L. et al. ACS Nano. p. acsnano.8b07524. 2019.
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