Sleep disorders affect multiple physiological systems, with respiratory, cardiovascular, and neurological consequences. Conditions such as sleep apnea, insomnia, narcolepsy, and circadian rhythm disorders can disrupt breathing, oxygenation, cardiac function, brain activity, and behavior.
Preclinical sleep research enables researchers to investigate these interconnected effects through integrated respiratory, cardiovascular, EEG/EMG, and behavioral monitoring. Wireless telemetry combined with synchronized video provides continuous, minimally invasive monitoring of freely moving animals, supporting comprehensive assessment of sleep, breathing, cardiac function, neural activity, and behavior.
Plethysmography utilizes a non-invasive technique which allows conscious polysomnography, or sleep studies, in unanaesthetized, spontaneously breathing subjects. This technique provides continuous high-fidelity respiratory recordings during sleep and wakefulness based on measures of tidal volume, respiratory rate and minute ventilation.
Integration of electroencephalogram (EEG) & electromyography (EMG) recordings with respiratory signals offer a detailed characterization of the cardiopulmonary contributions in a sleep-disordered breathing state. Plethysmography systems may also integrate with a mass flow controller to measure these respiratory effects under chronic intermittent periods of hypoxia, a key feature of sleep apnea.
Sleep disturbances are commonly associated with neurological and cardiovascular diseases. easyTEL+ implants acquires multiple biopotentials (EEG, EMG, ECG, EOG), blood pressure, temperature, and activity to study changes in sleep in relation to epilepsy, hypertension, circadian rhythms, and more in small to large animals.
While the small animal implants acquire up to 2 biopotentials for up to 150 days, the large animal implants can record up to 4 biopotentials for up to 95 days.
The easyTEL+RP reusable telemeter acquires up to four low-noise biopotentials (cortical or penetrating EEG, EMG, ECG, EOG) as well as activity from rodents 200g or more.
In large animals, it collects neurological and activity changes without surgical implantation of the telemeter. Subjects are equipped with an external transmitter housed in a jacket or a helmet with surface leads paced on the scalp.
Externalized transmitters can be reused across subjects, cohorts, and studies, reducing start-up costs for behavioral studies requiring a large subject pool. The custom design of our transmitters (electrodes, electrode wires, polarity) combined with user configurable sampling rate, resolution, and gain, provide users with various study design options. Easily exchangeable batteries last for up to 150 hours of continuous recordings.
EEG+ offers automated and/or manual sleep scoring and spectral analysis with optional advanced cardiovascular analysis modules to assist in interdisciplinary studies.
Our sleep scoring module scores based on 4 different stages which are active wake (AW), quiet wake (QW), slow wave sleep (SWS), and rapid eye movement (REM), utilizing user-defined logic tree analysis. Adjustable epoch and step length allow for custom binning and reporting of sleep stages across variable time intervals. Results are visualized via trend graphs and reports with optional synchronized video.
Save time evaluating SCIREQ equipment by having a SCIREQ Application Specialist conduct a custom
literature research. Researchers will receive an email report showing SCIREQ publications relevant to their specific application research area, along with custom equipment recommendations and commentary.
