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Alzheimer’s Disease

Alzheimer’s Disease is a progressive neurodegenerative disorder that primarily affects memory, cognition, and behavior. Key pathological features include the accumulation of amyloid plaques and tau tangles in the brain, which disrupt neural communication and cognitive functions. Understanding Alzheimer’s disease (AD) through preclinical studies is crucial for developing effective treatments. In addition to dementia AD patients often also experience respiratory disturbances that are critical to understand through pre-clinical research.

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vivoFlow+

Plethysmograph

inExpose

Modular Exposure Solution

Plethysmography

vivoFlow+

In addition to dementia, AD patients experience respiratory disturbances. Indeed, Alzheimer’s disease is often associated with pneumonia, shortness of breath, respiratory muscle weakness, and obstructive sleep apnea (Wrzesień, A., 2024) .

Whole‑body plethysmography is used in rodent AD models to estimate tidal volume, thereby offering critical insights into disease etiology and progression.

Modular Exposure Solution

inExpose

Recent studies identified environmental pollution as a potential key contributor to neurodegeneration (Helen M. Butler, 2025). To investigate the effect of pollution on the brain, the inExpose is perfectly suited. It has been specifically designed for consistent, precise delivery of a pollutant concentration by controlling air flow rates.

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