Harmful particulates, biological materials, gaseous exhaust, as well as other environmental pollutants may enter the body via the lungs through inhalation exposure.
Artificially or naturally occurring environmental pollutants have been associated with increasing incidences of morbidity and mortality from cardiovascular and respiratory disorders. Pollutant deposition along the inhalation pathway may cause widespread effects of varying severity, including local airway inflammation to large scale structural damages. Further, introduction of the pollutants into the blood stream may result in multiple systemic effects, promoting cardiovascular or neurological diseases.
The inExpose has been specifically designed for consistent, precise delivery of a pollutant concentration by controlling air flow rates. This is done through automated exposure profiles, which also help to reduce user error and minimize outcome variability among subjects, study, and research groups. The inExpose operates under various configurations and protocols to ensure that the subjects receive repeatable yet consistent pollutant exposures throughout experimentation.
The flexiVent captures crucial changes in mechanical properties of the conducting airways, terminal airways and parenchyma in response to environmental pollutants. The flexiVent is a comprehensive tool allowing an integrated assessment of various disease determinants (e.g. extent and pattern of induced damage) on lung function decline.
The induced changes in lung parenchyma resulting from pollutants and air born irritants are likely to result in impaired breathing patterns, which can be captured repeatedly in conscious spontaneously breathing subjects using a whole body plethysmograph.
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