vivoFlow+ Plethysmography

vivoFlow+ Whole Body Plethysmograph allows studying pulmonary function in conscious, spontaneously breathing laboratory subjects. The standard barometric plethysmography technique measures flow and pressure changes that occur while the subject is breathing, before and after exposure to a drug or other challenges. It is often used for longitudinal studies where the subjects are studied for multiple hours on successive experiment days.

Features & Benefits

Freely moving mice, rats and guinea pigs (rabbit, ferret, dog, pig, primate on request)
Non-invasive measurements: No surgery – monitor the same animal day after day
Ease of use: Removable bucket chamber and hinged lid allows fast cleaning, easy placement and
removal of subjects.
Data reproducibility: Patented concentric pneumotachograph for industry leading noise cancellation.» Reduced acclimation time and variability between baseline values: The amber tinted chamber allows
the animals to quickly adjust to the chamber and settle into a quiet breathing pattern, as they do not
typically see amber wavelengths.
Fully integrated system: Separate module encloses sensitive components preventing risk of damage
while allowing easy removal of the subject chamber for cleaning.
Noise-free air renewal, with regulated ventilation

Applications for Whole Body Plethysmograph

AEROSOL DELIVERY

A nebulizer controller can be integrated into the vivoFlow+ electronics box, and used in conjunction with the
nebulizer head (Aeroneb® Lab Pro Nebulizer from Aerogen Inc.) to generate an aerosol environment within
the vivoFlow+ chamber:

Dedicated nebulizer and independent controls for each chamber
Nebulization automated through IOX software
Parallel and synchronized exposure across all chambers

EXPOSURE TO GAS MIXTURE WITH MASS FLOW CONTROLLER

Evaluate the effect of hypoxia, hyperoxia and hypercapnia.
Up to 3 gases can be controlled (e.g O2 + N2 + CO2 or air + CO2)
Full automation possible through IOX2 software protocols

DATA ACQUISITION & ANALYSIS

IOX software : Data recording, real-time analysis & display, synchronized video recording, nebulization
remote control with large variety of nebulization protocols
Datanalyst software: Data post-processing
GLP compliance : access control, audit-trail, electronic signature

See all of our products and applications.

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