Society of Toxicology 2025 Hosted Session
Hosted Session – Challenges in Modeling Complex Smoke Exposure: Optimizing Tools and Techniques for Reproducibility
SCIREQ hosted a free in-person session on March 18th at 12:15-1:15 pm EST. The event was held at the Orange County Convention Center in Room W209A.
General Session Description: In this hosted session, we explored the key challenges and best practices in modeling complex smoke exposure for preclinical research. A special focus was placed on optimizing tools and techniques to better simulate real-world conditions, ensuring that preclinical models are robust and translatable to human health outcomes. Practical insights into enhancing reproducibility across different smoke exposure platforms were discussed, providing a roadmap for advancing smoke exposure research.
Download Event Summary:
Speaker Spotlight:
Dr Jeff Crosby – Ionis Pharmaceuticals Inc
Bio: Jeff Crosby has dedicated over 20 years to Ionis Pharmaceuticals, where he leads a team focused on developing innovative treatments for pulmonary diseases. His group specializes in addressing conditions such as asthma, COPD, IPF, pulmonary hypertension, and cystic fibrosis, with an emphasis on utilizing inhaled RNA therapeutics to advance care for these challenging conditions.
Talk Title: Characterizing short-term and long-term Smoke-induced COPD models
Session Outline:
- COPD Background
- Short-term Cigarette Smoke COPD models
- 4-Month Cigarette Smoke/LPS COPD model
- Utilizing model to test RNA therapeutics
- Whole transcriptome expression analysis to
compare model to human COPD
- Conclusions
Dr Amit Gaggar – The University of Alabama in Birmingham
Bio: Dr. Amit Gaggar is an experienced pulmonologist based in Birmingham, Alabama, with over 20 years of practice. He is affiliated with leading hospitals such as the University of Alabama at Birmingham Hospital and Birmingham VA Medical Center. Dr. Gaggar specializes in treating lung and respiratory conditions, including asthma, COPD, cystic fibrosis, and pleural disease.
Talk Title: Exposure Studies as A Method to Identifying Mechanisms in COPD
Featured Products
in vivo, ex vivo and in vitro Smoke Exposure
The expoCube is an Air Liquid Interface (ALI)/Transwell in vitro / ex vivo exposure system that efficiently deposits aerosols onto cells and tissues. When combined with SCIREQ’s inExpose® inhalation exposure platform, the expoCube allows researchers to integrate in vitro, ex vivo and in vivo models, optimizing compound usage while adhering to the 3Rs principle.
The expoCube features:
- Reproducibility: Efficient, uniform, and precise exposure of particulates onto target cells and tissues.
- Precision: Optimized flow paths using advanced computational fluid dynamics (CFD) modelling.
- Deposition: Patented thermophoresis, increasing the deposition efficiency of small particles without imparting unnatural electrostatic charges onto the aerosols.
