With almost two decades of research and development, we have refined the flexiVent system to offer researchers the most detailed measurements in preclinical respiratory mechanics. The flexiVent solution is accuratereproducible and proven.


The flexiVent is the only system currently available that combines forced expirations with standard mechanics measurements in a single set-up.


The flexiVent is a sensitive device that offers precise control of experimental conditions, allowing researchers to determine functional phenotypes (see Phenotyping Cystic Fibrosis with the flexiVent), detect differences in disease severity (see COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosisand much more.

Furthermore, distinction between a subject’s airway versus tissue mechanics can be discerned in a matter of seconds, a detailed measurement unique to the flexiVent (see Assessing Airway Hyperresponsiveness using flexiVent). The flexiVent is comprehensive and easily permits a variety of measurements using a single protocol, providing the most information within one platform.

Detailed insights are obtained rapidly, resulting in fewer false positives, critical for drug development studies (see The flexiVent in the Astham Drug Development Process) and allowing for higher throughput without sacrificing measurement quality.


flexiWare software can estimate aerosol dose delivered to each subject, while characterizing losses due to rain-out.


Automated protocols are executed with a mouse click and offer precise control whereby each measurement is taken at the same timepoint, in the same manner, for each subject. This allows accurate comparison between groups in real-time without further analysis, as evidenced during administration of inhaled aerosol delivery or when using a micro-CT scanner gated with ventilation (read Gated Thoracic Imaging with the flexiVent).

The flexiVent eliminates environmental conditions which may impact the measurements. Aspects of the protocol are seamlessly standardized including tidal volume, breathing rate, lung history and other ventilation parameters, ensuring the only true variable is the subject. For instance, our protocols automatically include controlled deep inflations to reset the subject’s lung history, bringing them back to baseline conditions.

With unparalleled accuracy and reproducibility, studies require fewer subjects. The typical flexiVent study group size is less than five subjects, resulting in less time and cost.


Several studies using the flexiVent have been published in top journals such as Science and Nature.


Thorough validation of SCIREQ products occurs both by our experienced in-house scientific team and in collaboration with well-established members of the research community. The flexiVent is trusted and highly recommended by many top scientists and reviewers as featured in over 1,100 flexiVent publications covering a wide range of applications.