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The use of the flexiVent FX in testing inhaled β agonists during an allergic model bronchoconstrictor challenge
By SCIREQ
In Applications, Publications, Uncategorized
Posted February 15, 2021

The use of the flexiVent FX in testing inhaled β agonists during an allergic model bronchoconstrictor challenge

1. EXPERIMENTAL GOAL The forced oscillation technique (FOT) using the flexiVent has been the gold standard for pulmonary function tests (PFTs) in small animal in vivo studies for many years2,3. [...]

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Development of a Standardized Mouse Model for Nose-Only Inhaled Cannabis
By SCIREQ
In Uncategorized
Posted November 6, 2020

Development of a Standardized Mouse Model for Nose-Only Inhaled Cannabis

Cannabis is one of the most popular recreational drugs used worldwide. Since the recent legalization of marijuana across several countries and states, there is an increased interest in research [...]

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Diabetes associated fibrosis- in vivo functional assessment
By SCIREQ
In Publications, Uncategorized
Posted October 29, 2020

Diabetes associated fibrosis- in vivo functional assessment

Kumar et al. (2020) recently published a novel manuscript that combined work on cellular and mouse models shows that hyperglycemic conditions and the resultant metabolic alterations cause DNA [...]

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New insights from AITox 2020!
By SCIREQ
In Conferences & Events, Uncategorized
Posted October 26, 2020

New insights from AITox 2020!

New insights from AITox 2020! The  AITox seminars this year were quite interesting and informative, the organizers did a great job pivoting into the virtual world! If you missed the opportunity [...]

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Moving From 3R4F to 1R6F Cigarettes & The Importance of Puff Attributes on Results
By SCIREQ
In Applications, Technique & Measurement, Uncategorized
Posted October 22, 2020

Moving From 3R4F to 1R6F Cigarettes & The Importance of Puff Attributes on Results

In cigarette and e-cigarette studies, the initial composition of the compound being aerosolized, as well as puffing topography has appreciable effects on the puff characteristics and downstream [...]

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K18-hACE2 Mice as a SARS-CoV-2 Infection Model
By SCIREQ
In Applications, flexiVent, Uncategorized
Posted October 19, 2020

K18-hACE2 Mice as a SARS-CoV-2 Infection Model

Since COVID-19 was declared a global pandemic in March 2020, a massive wave of mobilization has been seen from various companies and organizations at different fronts, to not only help fight the [...]

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COVID-19, Vaping, and EVALI
By SCIREQ
In Applications, flexiVent, Uncategorized
Posted September 24, 2020

COVID-19, Vaping, and EVALI

COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19. However, studies have [...]

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E-Cigarette-Induced Pulmonary Inflammation, Dysregulated Repair And The Role Of nAChrRα7
By SCIREQ
In Uncategorized
Posted July 3, 2020

E-Cigarette-Induced Pulmonary Inflammation, Dysregulated Repair And The Role Of nAChrRα7

Relative to traditional cigarettes, E-cigarette use is increasing due to the widespread perception of e-cigarettes being a healthier alternative. More recently, concern about e-cigarette use is [...]

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New Insights From Pressure-Volume Loops
By SCIREQ
In Uncategorized
Posted May 13, 2020

New Insights From Pressure-Volume Loops

New insights from pressure-volume loops Lung function measurements with the flexiVent frequently include Pressure-Volume (PV) loops for insight on the intrinsic elastic properties of the [...]

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Combined Airway Physiology & Cardiovascular Hemodynamics in Mice
By SCIREQ
In Uncategorized
Posted April 24, 2020

Combined Airway Physiology & Cardiovascular Hemodynamics in Mice

Chronic lung diseases (CLDs) such as COPD, emphysema, interstitial lung fibrosis impair airflow, alter lung elastance, and impact pulmonary vascular hemodynamics which could result in ventricle [...]

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