The Usefulness Of Recruitment Manoeuvres
Atelectasis or airway closure spontaneously develops following anaesthesia and mechanical ventilation. This progressive loss in lung volume can have a significant impact on the subject’s
Let’s Talk About Impedance
The current state-of-the-art in pre-clinical lung function measurements is the evaluation of the mechanical properties of the respiratory system using FOT.
Lung Function in Conscious Subjects
Viruses are constantly changing through mutation, and currently, there are several variants of the SARS-CoV-2 virus that causes COVID-19.
The use of the flexiVent FX in testing inhaled β agonists during an allergic model bronchoconstrictor challenge
The forced oscillation technique (FOT) using the flexiVent has been the gold standard for pulmonary function tests (PFTs) in small animal in vivo studies for many years2,3. These FOT measurements provide
Hypersensitive Response in Asthmatic Guinea Pigs Following House Dust Mite Exposure
Due to the wide variety of strains available and ease of procurement and care, the mouse dominates in vivo pre-clinical research. Although a robust model, important divergences from human physiology makes
vivoFlow for Preclinical SARS-CoV-2 Hamster Studies
As in humans, the Angiotensin I Converting Enzyme 2 (ACE2) receptors of hamsters naturally permit binding of the SARS-CoV-2 virus spike protein. This suggests that hamsters are an important
New insights from AITox 2020!
The AITox seminars this year were quite interesting and informative, the organizers did a great job pivoting into the virtual world! If you missed the opportunity to attend, here are some highlights and what we learned.
Dynamic in-vivo imaging
Airway hyperresponsiveness (AHR) is a very complex relationship between smooth muscle and localized inflammation with little known about the exact physiology behind a response.
FlexiVent – Used in Recent Pulmonary Fibrosis Research
FlexiVent – Used in Recent Pulmonary Fibrosis Research Pulmonary fibrosis describes a condition in which the normal lung anatomy is replaced by a process of active remodeling, deposition of extracellular matrix and dramatic changes in the phenotype of both fibroblasts and alveolar epithelial cells. This condition can be idiopathic, as in idiopathic pulmonary fibrosis (IPF), […]
Function Follows Form and Form Follows Function
Function follows form and form follows function The flexiVent makes assessing mechanical properties of the lung a relatively simple undertaking. However, understanding the underlying physiological processes and mathematical modelling can be daunting. A background in pulmonary structure, function, and of the forces at play within the system are key to making the most of the provided outcomes. […]