The Usefulness Of Recruitment Manoeuvres
Atelectasis or airway closure spontaneously develops following anaesthesia and mechanical ventilation. This progressive loss in lung volume can have a significant impact on the subject’s
Let’s Talk About Impedance
The current state-of-the-art in pre-clinical lung function measurements is the evaluation of the mechanical properties of the respiratory system using FOT.
The use of the flexiVent FX in testing inhaled β agonists during an allergic model bronchoconstrictor challenge
The forced oscillation technique (FOT) using the flexiVent has been the gold standard for pulmonary function tests (PFTs) in small animal in vivo studies for many years.
Hypersensitive Response in Asthmatic Guinea Pigs Following House Dust Mite Exposure
Due to the wide variety of strains available and ease of procurement and care, the mouse dominates in vivo pre-clinical research. Although a robust model, important divergences from human physiology makes
vivoFlow for Preclinical SARS-CoV-2 Hamster Studies
As in humans, the Angiotensin I Converting Enzyme 2 (ACE2) receptors of hamsters naturally permit binding of the SARS-CoV-2 virus spike protein. This suggests that hamsters are an important
FlexiVent – Used in Recent Pulmonary Fibrosis Research
Pulmonary fibrosis describes a condition in which the normal lung anatomy is replaced by a process of active remodeling, deposition of extracellular matrix and dramatic changes in the phenotype of both fibroblasts and alveolar epithelial cells. This condition can be idiopathic, as in idiopathic pulmonary fibrosis (IPF), or secondary to genetic disorders, autoimmune disorders or exposure to environmental toxins, chemical warfare, drugs, foreign antigens or radiation
Function Follows Form and Form Follows Function
The flexiVent makes assessing mechanical properties of the lung a relatively simple undertaking. However, understanding the underlying physiological processes and mathematical modelling can be daunting. A background in pulmonary structure, function, and of the forces at play within the system are key to making the most of the provided outcomes.
To Open or Close the Lungs – That Is the Question!
To Open or Close the Lungs – That Is the Question! Although often necessary, mechanical ventilation of small animals during pulmonary measurements can lead to both acute and chronic damage to their lungs, also known as ventilator-induced lung injury (VILI). The injury happens as a result of the frequent opening and closing of alveolar air […]
Longitudinal Studies With The flexiVent to Acquire Lung Mechanics
When developing an appropriate protocol to assess respiratory mechanics, there is a trade-off between accuracy of the measurements and the invasiveness of the technique. The flexiVent favours an invasive technique, producing results that are unparalleled in accuracy.
QuickPrime Measurements for Deeper Insight
QuickPrime Measurements for Deeper Insight What is the forced oscillation technique (FOT)? Simply put, the forced oscillation technique is: Pausing ventilation Sending a test signal to the lungs Measuring the subject’s response The test signal is either a single frequency (matching the breathing frequency of the subject) or made up of multiple frequencies. When adding […]