Understanding Lung Biomechanics in Asthma By Combining ex vivo With in vitro
Asthma remains a complex and multifactorial disease, with airway hyperresponsiveness to methacholine being a hallmark feature. A recent study by Rojas-Ruiz (2025) utilizes SCIREQ’s innovative physioLens (ex vivo) and flexiVent (in vivo) platforms to shed light on the interplay between lung tissue compliance and methacholine response, offering new insights into the mechanisms driving asthma pathology.
Dual Benefits of Compound 17B For Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a progressive, life-threatening condition characterized by increased pulmonary arterial pressure, vascular remodeling, and persistent inflammation. Despite advances in treatment, current therapies—such as sildenafil, iloprost, and riociguat—primarily focus on reducing symptoms by dilating blood vessels.
PCLS: An ex-vivo Window Into Lung Disease And Drug Discovery
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses.
Advancing Fibrosis Studies: The Impact of Repeated Lung Function Monitoring
Lung function testing (LFT) is crucial for diagnosing and monitoring chronic lung diseases like idiopathic pulmonary fibrosis (IPF). In animal studies, particularly with mice, LFT is often used as an endpoint, requiring multiple animals to assess disease progression.
Reducing Variability in Lung Slice Analysis
A recent publication by Boucher et al (2024) streamlines this process of quantifying airway constriction in Precision Cut Lung Slices (PCLS) by using the new physioLens automated solution for physiology and image analysis. This new solution enables researchers to conduct high-throughput screening of airway constriction with unprecedented precision and efficiency.
PCLS: Unraveling the Intricacies of Asthma Research
In the quest for better treatment options, precision cut lung slices (PCLS) have emerged as a cutting-edge tool in preclinical asthma research