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Recent Blogs
PCLS: An ex-vivo Window Into Lung Disease And Drug Discovery
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses.
Validating The Bleo-Induced Mouse Model For Drug Discovery
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs, which severely impairs lung function over time.
Advancing Fibrosis Studies: The Impact of Repeated Lung Function Monitoring
Lung function testing (LFT) is crucial for diagnosing and monitoring chronic lung diseases like idiopathic pulmonary fibrosis (IPF). In animal studies, particularly with mice, LFT is often used as an endpoint, requiring multiple animals to assess disease progression.
Reducing Variability in Lung Slice Analysis
A recent publication by Boucher et al (2024) streamlines this process of quantifying airway constriction in Precision Cut Lung Slices (PCLS) by using the new physioLens automated solution for physiology and image analysis. This new solution enables researchers to conduct high-throughput screening of airway constriction with unprecedented precision and efficiency.