Navigating the Future of Preclinical Research: Aligning with the FDA’s Roadmap on Animal Testing
The Food and Drug Administration’s (FDA) recent Roadmap to Reducing Animal Testing in Preclinical Safety Studies marks a pivotal shift toward the adoption of innovative, human-relevant methodologies commonly known as New Approach Methodologies (NAMs).
Understanding Lung Biomechanics in Asthma By Combining ex vivo With in vitro
Asthma remains a complex and multifactorial disease, with airway hyperresponsiveness to methacholine being a hallmark feature. A recent study by Rojas-Ruiz (2025) utilizes SCIREQ’s innovative physioLens (ex vivo) and flexiVent (in vivo) platforms to shed light on the interplay between lung tissue compliance and methacholine response, offering new insights into the mechanisms driving asthma pathology.
The Impact of Cannabis Vapor on the Lungs and What We Learn from the Right Model
As cannabis use increases, so does the availability of products marketed as safe alternatives to smoking. One of these products is the dry herb vaporizer, which heats the cannabis flower without burning it. This process releases cannabinoids for inhalation. But how safe are these products?
A New Mouse Model for SARS-CoV-2 Studies Beyond The Respiratory System
For five years since the onset of the COVID-19 pandemic, the scientific community delved deep into the mysteries of the SARS-CoV-2 virus, to understand its impact on our health and develop antiviral therapies and vaccine.
The Effect of Combined Exercise and Diet on Obese Mice
Obesity is a metabolic condition resulting from an imbalance between the energy consumed and the energy expended. This is often caused by an increase in the intake of calorie-dense foods and a decrease in physical activity, leading to an abnormal build-up of fat. Such fat accumulation can have serious health consequences, raising the risk of chronic diseases like cardiovascular conditions, diabetes, and some cancers. It is usually associated with a higher prevalence of non-alcoholic fatty liver disease (NAFLD) and asthma.
The Role Of Setmelanotide In Improving Hypercapnic Chemosensitivity And Weight Loss In Male Mice
Obesity is a significant contributor to respiratory disorders such as Obesity Hypoventilation Syndrome (OHS) and sleep apnea, both of which are characterized by reduced respiratory chemosensitivity. These conditions not only impair breathing but also exacerbate the health risks associated with obesity.
Precision Aerosol Therapy Through AI And flexiVent-Controlled Delivery
Yang, L., et al (2024) introduces LungVis 1.0, an AI-driven imaging platform integrating light sheet fluorescence microscopy (LSFM) and deep learning for mapping nanoparticle (NP) deposition across murine lungs. The research highlights the advantages of aerosol-based delivery methods over traditional liquid-based approaches, emphasizing the uniformity of NP deposition in distal alveolar regions achieved via ventilator-assisted aerosol delivery (VAAD).
Role Of Precision Cut Lung Slices (PCLS) In Advancing Copd Preclinical Research
Chronic Obstructive Pulmonary Disease (COPD) is a global health burden characterized by persistent airflow limitation and progressive lung damage. Despite extensive research, translating findings from bench to bedside remains a challenge.
Dual Benefits of Compound 17B For Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a progressive, life-threatening condition characterized by increased pulmonary arterial pressure, vascular remodeling, and persistent inflammation. Despite advances in treatment, current therapies—such as sildenafil, iloprost, and riociguat—primarily focus on reducing symptoms by dilating blood vessels.
New Methodology: Analyzing Volatile Organic Compounds With The flexiVent System
Volatile organic compounds (VOCs) in breath are emerging as vital biomarkers in medical research, offering a non-invasive glimpse into metabolic and physiological processes. A recent publication by Talor, A., et al (2024) has introduced a novel method for capturing VOCs from the breath of intubated mouse models.