Could a Novel BET Inhibitor Protect the Lungs from Secondhand Smoke?
Nearly half of the U.S. population remains at risk from the silent threat of secondhand smoke. Chronic exposure to triggers a cascade of inflammation and vascular damage that can lead to irreversible conditions like COPD and emphysema.
Integrating flexiVent and XV: Detecting Functional Impairment in Pre-Radiographic Lung Cancer
A recent pilot study by Smith et al (2025) has broken new ground by combining two
powerhouse technologies—the flexiVent and X-ray Velocimetry (XV)—to map the
functional decline of the lungs during tumor progression.
Precision Particles for Persistent Asthma
A promising solution for Asthma: an innovative dry powder for inhalation (DPI) designed for controlled release and prolonged lung retention.
Breathing Life into Nanodrug Research: A Lung-on-Chip Revolution
When it comes to inhaled therapies, one of the biggest challenges is replicating the complex dynamics of human breathing in a controlled lab setting. Traditional aerosol exposure systems often fall short—they can deliver particles, but they don’t mimic the realistic airflow patterns and mucociliary clearance that define our respiratory system.
Herbal Medicine Treatment for Micro-plastic Induced Lung Damage
Studies demonstrate the ability of Polystyrene microplastics to penetrate deep into the lungs, where they can induce oxidative stress, inflammation and airway remodeling. A recent study by Balkrishna et al. (2025) investigates these effects in a murine model and evaluates Bronchom, a plant-based herbal formulation, as a potential protective intervention.
Shaping the Future of Pulmonary Fibrosis Therapy with Inhaled Microgels
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure.
Cold Air and Pollution: A Combined Challenge for the Airways
Exercise-induced bronchoconstriction (EIB) is a hallmark of asthma and other respiratory diseases. It occurs when vigorous physical activity triggers transient and reversible airway narrowing. Environmental factors such as cold, dry air and air pollution are known to exacerbate symptoms, particularly in athletes and individuals exercising in urban environments.
joVE – In vitro Cannabis Exposures of Lung Epithelial Cells
Cannabis is used by an estimated 192 million people around the world. Most people use cannabis through the inhalation of cannabis smoke, which contains combustion by-products that can negatively affect lung health. . There is currently no standardized in vitro model for assessing the effects of dry cannabis vapor.
Navigating the Future of Preclinical Research: Aligning with the FDA’s Roadmap on Animal Testing
The Food and Drug Administration’s (FDA) recent Roadmap to Reducing Animal Testing in Preclinical Safety Studies marks a pivotal shift toward the adoption of innovative, human-relevant methodologies commonly known as New Approach Methodologies (NAMs).
Understanding Lung Biomechanics in Asthma By Combining ex vivo With in vitro
Asthma remains a complex and multifactorial disease, with airway hyperresponsiveness to methacholine being a hallmark feature. A recent study by Rojas-Ruiz (2025) utilizes SCIREQ’s innovative physioLens (ex vivo) and flexiVent (in vivo) platforms to shed light on the interplay between lung tissue compliance and methacholine response, offering new insights into the mechanisms driving asthma pathology.