Precision-Cut Lung Slices (PCLS) help researchers understand pathophysiological mechanisms associated with various respiratory diseases. The physioLens is a scientific platform that provides accurate physiological and image-based outcomes in a reproducible fashion. It includes an automated microscope and fluid handling system.
The airway smooth muscle plays an undeniable role in asthma. The excessive amount of contraction it can generate as well as the enhanced sensitivity have been associated with key characteristics of asthma, namely bronchoconstriction and airway hyperresponsiveness. Using the physioLens with PCLS allows for airways to be individually characterized for bronchoconstriction. Details about the size, shape and location of the airways are all acquired. External influences are removed, allowing for direction understanding of bronchoconstriction. This technique is an emerging pharmacological tool.
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