Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Since COVID-19 was declared a global pandemic in March 2020, a massive wave of mobilization has been seen from various companies and organizations at different fronts
State of cannabis research Since the recent legalization of recreational cannabis, there is an increased interest in research into both the pulmonary effects of inhaled cannabis, as well as improving our understanding of the endocannabinoid
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
The emergence of novel zoonotic outbreaks such as COVID-19 continue to result in high mortality rates, as seen in previous epidemics (i.e SARS & MERS).
Rett syndrome is a severe neurodevelopmental disease resulting from a loss of function mutation in MeCP2; an epigenetic modulator of transcription regulation
The Lung Epithelial Protein PDIA3’s Role In Airway Mechanics During Influenza Infection Protein disulfide isomerases (PDIs) are a family of chaperone enzymes within the eukaryotic
Refined Preclinical Study Design with Spirometry Spirometry is a widely known clinical pulmonary test measuring volumes and flows expired by patients that is used to
inExpose Featured in recent nature publication Congratulations to Dr. Blackwell’s team at Vanderbilt University who recently published in Nature Communications1 with the inExpose! As you may
FlexiVent – Used in Recent Pulmonary Fibrosis Research Pulmonary fibrosis describes a condition in which the normal lung anatomy is replaced by a process of
Function follows form and form follows function The flexiVent makes assessing mechanical properties of the lung a relatively simple undertaking. However, understanding the underlying physiological processes and
To Open or Close the Lungs – That Is the Question! Although often necessary, mechanical ventilation of small animals during pulmonary measurements can lead to
Longitudinal Studies With the flexiVent to Acquire Lung Mechanics When developing an appropriate protocol to assess respiratory mechanics, there is a trade-off between accuracy of
Empower Yourself Attending a training such as the Phenotyping Mice Models of Human Lung Disease organized by the Jackson Laboratory is a great way to advance skillsets
E-cigarette vapour deposition E-cigarette vapour composition is influenced by a number of factors. Some of which relate to the device physically (battery charge, wattage/temperature control,
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