Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Since COVID-19 was declared a global pandemic in March 2020, a massive wave of mobilization has been seen from various companies and organizations at different fronts
State of cannabis research Since the recent legalization of recreational cannabis, there is an increased interest in research into both the pulmonary effects of inhaled cannabis, as well as improving our understanding of the endocannabinoid
Longitudinal studies offer a wealth of information, particularly for diseases progression or development studies. In addition, smaller sample sizes are possible to accumulate significant data, as subject assessment is possible at multiple time points.
Animal models are crucial in advancing our knowledge and understanding of pulmonary diseases. Using alternatives models, such as computer simulations, is simply not advanced enough to elucidate all the biological mechanisms inside a living creature.
Work of Breathing & Airway Compliance The latest release of flexiWare (8.2) brings with it the capacity to assess both work of breathing (WOB) and
Ultrapotent Miniproteins Protect Against SARS-CoV-2 Lung Inflammation and Pathology A recent study published in Cell Host & Microbe by Dr. Michael Diamond’s group at the
Preclinical Neonate Research Preclinical Pediatrics and Neonate Research Pediatrics and neonatology involves learning more about development and growth through the first stages of life. Early lung
Asthma – From Mouse To Man “The assessment of lung function endpoints used in preclinical drug testing may hold the key to translation of drug
Atelectasis or airway closure spontaneously develops following anaesthesia and mechanical ventilation. This progressive loss in lung volume can have a significant impact on the subject’s
The current state-of-the-art in pre-clinical lung function measurements is the evaluation of the mechanical properties of the respiratory system using FOT.
Mice strain can have an important impact on research, as certain strains are better suited to some applications than others.
Viruses are constantly changing through mutation, and currently, there are several variants of the SARS-CoV-2 virus that causes COVID-19.
Throughout the global COVID-19 pandemic, there has been a noticeably higher mortality rate in males compared to females. Though the mechanism that causes this remains unknown, Dr. Sharma and Dr. Zeki hypothesize
Viruses are constantly changing through mutation, and currently, there are several variants of the SARS-CoV-2 virus that causes COVID-19.
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