Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Since COVID-19 was declared a global pandemic in March 2020, a massive wave of mobilization has been seen from various companies and organizations at different fronts
State of cannabis research Since the recent legalization of recreational cannabis, there is an increased interest in research into both the pulmonary effects of inhaled cannabis, as well as improving our understanding of the endocannabinoid
Asthma is a complex disease, whose principal characteristics include reversible airflow obstruction, airway hyperresponsiveness (AHR), airway inflammation, airway remodeling and mucus hypersecretion. Airway mucus hypersecretion specifically is an important and dangerous pathophysiological manifestation of asthma.
This years ATS meeting took place in San Francisco, and our team was there to show off the new and exciting developments that you have come to expect from SCIREQ. With recent developments to both the flexiVent and inExpose systems, there was a lot to see. Come stay updated.
The airways contribute to the total compliance of the respiratory system and, over the last 50 years or so, researchers have had an interest in establishing their specific contribution Indeed, the airway diameter as well as the volume of air available for ventilation following inspiration can both be affected by a change in the distensibility of the airways.
At this year’s annual meeting, SCIREQ focused our discussions around our plethysmography system – the vivoFlow – which permits a continuous, non-invasive assessment of breathing patterns in conscious subjects, and allows for automated exposure to gas challenges, as well as aerosol delivery, wired and vascular access.
SCIREQ recently attended this year’s Society of Toxicology (SOT 2022) Annual Meeting and ToxExpo. A common topic was in vitro exposure with air pollutants or wood fire smoke exposure. In addition to the posters, here are some of the highlights from this year’s SCIREQ booth!
Obstructive sleep apnea syndrome (OSA) is a complete or partial airway obstruction that can cause significant physiological disturbances with various clinical impacts such as snoring, nocturnal awakening, or daytime sleepiness.
Pulmonary Fibrosis (PF) is a type of interstitial lung disease with a poor prognosis and response to current therapies. During the progress of this disease, the build-up of fibrotic tissue leads to an overall rigidity of lung architecture, leading to a gradual decline in lung function.
Acute lung injury (ALI) arises from factors as diverse as endotoxin exposure, chemical assault, acute particulate exposures or mechanical impacts, as seen in ventilator induced lung injury (VILI). ALI and VILI studies push the understanding of both fundamental breathing mechanics and general lung physiology to describe how damage occurs in the hopes of mitigating of damage.
Longitudinal studies offer a wealth of information, particularly for diseases progression or development studies. In addition, smaller sample sizes are possible to accumulate significant data, as subject assessment is possible at multiple time points.
Animal models are crucial in advancing our knowledge and understanding of pulmonary diseases. Using alternatives models, such as computer simulations, is simply not advanced enough to elucidate all the biological mechanisms inside a living creature.
Work of Breathing & Airway Compliance The latest release of flexiWare (8.2) brings with it the capacity to assess both work of breathing (WOB) and
Ultrapotent Miniproteins Protect Against SARS-CoV-2 Lung Inflammation and Pathology A recent study published in Cell Host & Microbe by Dr. Michael Diamond’s group at the
Welcome to SCIREQ’s knowledge center. You can find everything from software registration to document downloads to complete list of SCIREQ publications in this section. Everything you need to get the most out of your SCIREQ system.
