Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
COVID-19 has rapidly spread throughout the world and was declared a pandemic in March of 2020. Currently, there is no clinically validated treatment or vaccine for COVID-19.
Since COVID-19 was declared a global pandemic in March 2020, a massive wave of mobilization has been seen from various companies and organizations at different fronts
State of cannabis research Since the recent legalization of recreational cannabis, there is an increased interest in research into both the pulmonary effects of inhaled cannabis, as well as improving our understanding of the endocannabinoid
Mesenchymal stem cells (MSCs) have shown great promise in cell therapy for various diseases, including lung injury. However, recent research has focused on the therapeutic potential of extracellular vesicles (EVs) derived from MSCs.
The ability to time intervals is critical for fundamental animal behaviors such as anticipating rewarding or aversive events. However, the neurobiological basis of interval timing in Pavlovian associative learning is poorly understood.
Lung function testing is often considered of prime importance in preclinical respiratory research. Being integrative, functional, and translational, the conclusions of such assessments typically impact the decision-making process.
Exercising outdoors, particularly when done at high intensity and in polluted environments, could cause molecular alterations that could impact pulmonary function.
Lung function testing is often considered of prime importance in preclinical respiratory research. Being integrative, functional, and translational, the conclusions of such assessments typically impact the decision-making process.
Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.
Airway hyperresponsiveness (AHR) and exercise-induced bronchoconstriction (EIB) are conditions commonly affecting high-intensity athletes such as competitive swimmers.AHR and EIB in athletes have been well defined, however, studies focusing on immunological relevance in symptom onset may prove useful in developing preventative measures.
The impact of cigarette smoke (CS) exposure on the respiratory system can best be captured by evaluating changes in lung function coupled with assessments of morphology and structural composition. These measurements are both quantitative and can capture the extent of disease severity such as degree, pattern, and location of tissue destruction.
Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.
Isolated tissue baths, also known as organ chambers, are tools that have been used in the discipline of pharmacology for over 150 years to evaluate tissues contractility and relaxation response upon exposure to stimuli including the addition of various agonists1. This technique was used in one of the most breakthrough scientific findings in 1980 when the endothelium pioneers, Furchgott and Zawadski, discovered the signalling molecule nitric oxide in the cardiovascular system2 for which they were awarded the 1998 Nobel Price in physiology.
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lungs that has been a major public health problem, and has been the third leading cause of death worldwide. A large proportion of COPD deaths (~75%) are linked to tobacco smoking, which is now the primary risk factor in the development of the disease.
The current COVID-19 pandemic has highlighted the need for a rapid development of therapeutic approaches to treat respiratory diseases. Yet, respiratory therapeutic candidates have until now displayed a low success rate . As a result, development times are long and only a few novel mechanism respiratory therapeutic entities have been introduced over the last decades.
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