Air Liquid Interface
Exploring ALI Exposures: From Cell Lines to Endpoints

Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.

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State of Cannabis Research

State of cannabis research Since the recent legalization of recreational cannabis, there is an increased interest in research into both the pulmonary effects of inhaled cannabis, as well as improving our understanding of the endocannabinoid

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New Mouse Handling Recommendations For Improving Animal and Handler Well-being

All research model systems have unique strengths and challenges regarding the generalizability of data to other systems. Pre-clinical researchers attempt to describe and interact with human clinical phenotypes using animal models. These models allow manipulation and testing of scientific hypotheses within the context of a complex system, providing insights that may be impossible using in vivo methods or within the constraints of clinical interventions.

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Ending Support for Legacy Plethysmography

Our legacy plethysmograph system has officially retired starting September 1, 2019.

Over the past few years it has become increasingly difficult to support our legacy plethysmography data acquisition hardware and software, with considerable rises in costs associated with maintenance and support for existing systems. After careful consideration, it was decided to retire the legacy plethysmograph system.

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Mucolytic Treatment in Allergic Airway Disease

Asthma is a complex disease, whose principal characteristics include reversible airflow obstruction, airway hyperresponsiveness (AHR), airway inflammation, airway remodeling and mucus hypersecretion. Airway mucus hypersecretion specifically is an important and dangerous pathophysiological manifestation of asthma.

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American Thoracic Society 2022

This years ATS meeting took place in San Francisco, and our team was there to show off the new and exciting developments that you have come to expect from SCIREQ. With recent developments to both the flexiVent and inExpose systems, there was a lot to see. Come stay updated.

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Assessing the Airway Contribution To Total Respiratory Compliance

The airways contribute to the total compliance of the respiratory system and, over the last 50 years or so, researchers have had an interest in establishing their specific contribution Indeed, the airway diameter as well as the volume of air available for ventilation following inspiration can both be affected by a change in the distensibility of the airways.

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Experimental Biology 2022

At this year’s annual meeting, SCIREQ focused our discussions around our plethysmography system – the vivoFlow – which permits a continuous, non-invasive assessment of breathing patterns in conscious subjects, and allows for automated exposure to gas challenges, as well as aerosol delivery, wired and vascular access.

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SCIREQ at Society of Toxicology 2022

SCIREQ recently attended this year’s Society of Toxicology (SOT 2022) Annual Meeting and ToxExpo. A common topic was in vitro exposure with air pollutants or wood fire smoke exposure. In addition to the posters, here are some of the highlights from this year’s SCIREQ booth!

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Visualizing Lung Physiology in Response to Chemical and Mechanical Assaults

Acute lung injury (ALI) arises from factors as diverse as endotoxin exposure, chemical assault, acute particulate exposures or mechanical impacts, as seen in ventilator induced lung injury (VILI). ALI and VILI studies push the understanding of both fundamental breathing mechanics and general lung physiology to describe how damage occurs in the hopes of mitigating of damage.

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Longitudinal Studies with SCIREQ Systems

Longitudinal studies offer a wealth of information, particularly for diseases progression or development studies. In addition, smaller sample sizes are possible to accumulate significant data, as subject assessment is possible at multiple time points.

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Animal Models for Pulmonary Diseases

Animal models are crucial in advancing our knowledge and understanding of pulmonary diseases. Using alternatives models, such as computer simulations, is simply not advanced enough to elucidate all the biological mechanisms inside a living creature.

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Empowering researchers

Welcome to SCIREQ’s knowledge center. You can find everything from software registration to document downloads to complete list of SCIREQ publications in this section. Everything you need to get the most out of your SCIREQ system.