Validating The Bleo-Induced Mouse Model For Drug Discovery

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs, which severely impairs lung function over time.

Advancing Fibrosis Studies: The Impact of Repeated Lung Function Monitoring

Lung function testing (LFT) is crucial for diagnosing and monitoring chronic lung diseases like idiopathic pulmonary fibrosis (IPF). In animal studies, particularly with mice, LFT is often used as an endpoint, requiring multiple animals to assess disease progression.

Animal Models for Pulmonary Diseases

Animal models are crucial in advancing our knowledge and understanding of pulmonary diseases. Using alternatives models, such as computer simulations, is simply not advanced enough to elucidate all the biological mechanisms inside a living creature.

Diabetes associated fibrosis- in vivo functional assessment

Kumar et al. (2020) recently published a novel manuscript that combined work on cellular and mouse models shows that hyperglycemic conditions and the resultant metabolic alterations cause DNA

FlexiVent – Used in Recent Pulmonary Fibrosis Research

FlexiVent – Used in Recent Pulmonary Fibrosis Research Pulmonary fibrosis describes a condition in which the normal lung anatomy is replaced by a process of active remodeling, deposition of extracellular matrix and dramatic changes in the phenotype of both fibroblasts and alveolar epithelial cells. This condition can be idiopathic, as in idiopathic pulmonary fibrosis (IPF), […]

First Idiopathic Pulmonary Fibrosis Mouse Model

First Idiopathic Pulmonary Fibrosis Mouse Model Congratulations to Dr. Beers and his team for developing and phenotyping the first idiopathic pulmonary fibrosis mouse model! Pulmonary fibrosis mouse model – why do we need them? Mouse models are an important research tool for preclinical scientists. Alternatives including cells and computer simulations do exist, however they are not […]