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Airway Hyperreactivity in Chlorine Exposed EIB Swimmers Model

Airway hyperresponsiveness (AHR) and exercise-induced bronchoconstriction (EIB) are conditions commonly affecting high-intensity athletes such as competitive swimmers.AHR and EIB in athletes have been well defined, however, studies focusing on immunological relevance in symptom onset may prove useful in developing preventative measures.

Advantages of ALI Exposure – expoCube

in vitro cell exposure

Traditional submerged cell culture techniques have well-known limitations for aerosol exposure studies; for instance, the impact of exposure dilution within the media and the poor solubility/sedimentation of some exposure particles1. Air liquid interface (ALI) cultures are a technique whereby cells are grown on a microporous membrane insert, immersed in a media-containing well.

Tissue Baths in Respiratory Disease Models

Isolated tissue baths, also known as organ chambers, are tools that have been used in the discipline of pharmacology for over 150 years to evaluate tissues contractility and relaxation response upon exposure to stimuli including the addition of various agonists1. This technique was used in one of the most breakthrough scientific findings in 1980 when the endothelium pioneers, Furchgott and Zawadski, discovered the signalling molecule nitric oxide in the cardiovascular system2 for which they were awarded the 1998 Nobel Price in physiology.

Latest Advances in Preclinical SARS-CoV-2 Research

Covid-19

There has been incredible scientific effort and progress over the past two years geared at the protection and treatment of COVID-19. In this blog, we will highlight some significant recent advances in SARS-CoV-2 preclinical modelling, which use the inExpose to deliver inhaled target compounds and the flexiVent to characterize a full pulmonary function profile.

Dual Vaccination Protects Against Allergic Asthma in Mice

Dual vaccination against IL-4 and IL-13 using kinoids (a conjugate vaccine) is one of the therapeutic strategies suggested to neutralize the response induced by this type 2 inflammation. In recent studies by Conde et al 2021, House Dust Mite (HDM)-treated mice, which exhibit key characteristics of human chronic asthma, were used to test prophylactic and therapeutic dual vaccination efficiency in this allergic mouse model.

Animal Models for Pulmonary Diseases

Animal models are crucial in advancing our knowledge and understanding of pulmonary diseases. Using alternatives models, such as computer simulations, is simply not advanced enough to elucidate all the biological mechanisms inside a living creature.

Preclinical Neonate Research

pediatrics neonatology respiratory research equipment

Preclinical Neonate Research Preclinical Pediatrics and Neonate Research Pediatrics and neonatology involves learning more about development and growth through the first stages of life. Early lung development studies investigate the some of the most vulnerable stages of life and must overcome significant experimental challenges when working with small, fragile and uncooperative subjects. The research targets a […]

Asthma – From Mouse To Man

Asthma - From Mouse To Man

Asthma – From Mouse To Man “The assessment of lung function endpoints used in preclinical drug testing may hold the key to translation of drug efficacy from mouse to man¹.” Bench-to-bedside Mouse models have been and continue to be of invaluable importance in asthma research, for the elucidation of key disease pathways as well as […]